Publications by authors named "A Florescu"
Obstructive Sleep Apnoea (OSA) is associated with the development of cardiovascular disease (CVD); however, the risk is only weekly related to OSA severity traditionally determined by the apnoea-hypopnoea index. The Baveno classification was developed to improve patient selection who would benefit from OSA treatment in terms of symptoms improvement and CVD risk reduction. However, it is unclear how the classification relates to biomarkers of CVD risk.
View Article and Find Full Text PDFBackground: Medullary thyroid carcinoma (MTC), the third most frequent histological type of thyroid malignancy, may be found isolated or as part of multiple endocrine neoplasia type 2 (MEN2). One particular subtype of this autosomal dominant-transmitted syndrome includes an association with cutaneous lichen amyloidosis, although, generally, a tide genotype-phenotype correlation is described in patients who carry proto-oncogene pathogenic variants.
Methods: Our objective was to provide an endocrine perspective of a case series diagnosed with -positive familial MTC associated with cutaneous primary lichen amyloidosis amid the confirmation of MEN2.
Objectives: To quantify levels of two inflammation-related indexes, namely neutrophil-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) in systemic scleroderma patients and determine the association with clinical manifestations and features of heart ultrasound.
Methods: The study group consisted of 34 patients with diagnosis of systemic scleroderma which were admitted to the hospital during 2015-2019. Patient data included the presence and type of clinical manifestations of systemic scleroderma, chest imaging to screen for lung disease, heart ultrasound reports and the laboratory investigations needed to quantify inflammatory indexes.
Article Synopsis
- The study aimed to assess the potential of vitamin D, the neutrophil to lymphocyte ratio (NLR), and the systemic inflammation index (SII) as biomarkers for identifying flares in systemic lupus erythematosus (SLE).
- Researchers conducted a thorough examination and analyzed blood samples from individuals with SLE to evaluate their disease activity using established criteria (EULAR/ACR 2019).
- Results indicated that both NLR and SII are strong predictors of severe disease flares, while vitamin D levels showed a weaker connection to disease severity, suggesting a need for more research on its role.
Article Synopsis
- The study investigates the prevalence of transient and permanent hypoparathyroidism (hypoPT) after total thyroidectomy in 519 patients at a tertiary surgical center from 2018 to 2023.
- It finds that 26.97% of patients experienced postoperative hypoPT, with 4.23% classified as having permanent hypoPT after 12 months, while many patients recovered within that timeframe.
- Additionally, patients with hypoPT thyroiditis showed higher serum PTH levels at 3 months post-surgery compared to those with other thyroid issues, suggesting different recovery patterns depending on the underlying disease.