Publications by authors named "A Flisser"
Transcriptome profiling of macrophages persistently infected with human respiratory syncytial virus and effect of recombinant calreticulin on immune-related genes.
Front Microbiol
September 2024
Introduction: Human respiratory syncytial virus (hRSV) is a main cause of bronchiolitis in infants and its persistence has been described in immunocompromised subjects. However, limited evidence has been reported on the gene expression triggered by the hRSV and the effect of recombinant -derived calreticulin (rTsCRT).
Methods: Using a comprehensive microarray approach, we analyzed the transcriptome profile of a macrophage cell line that has supported hRSV persistence for over 150 passages.
Article Synopsis
- Cell migration plays a crucial role in the immune system, but it is not well-studied in pregnant animals, despite observed increases in spleen and lymph node sizes during pregnancy.
- In the study, researchers used a mouse model to analyze the movement of PKH26-stained immune cells from pregnant and non-pregnant mice to see how pregnancy affects cell distribution in lymphoid organs.
- Results showed that while more thymocytes were present in females compared to males, the movement of immune cells from pregnant and non-pregnant mice was similar, suggesting that larger spleen and lymph node sizes in pregnant mice may be due to leukocyte retention rather than differences in cell migration.
Fc-gamma receptor expression and cytokine responses to intravenous human immunoglobulin in whole blood from non-pregnant and pregnant women and newborns.
Adv Clin Exp Med
October 2024
Background: Intravenous immunoglobulin (IVIG) can suppress the inflammatory response in adults, but its role in pregnant women and newborns is poorly studied. While the adult immune system is considered mature, it is immature in neonates and suppressed in pregnancy. Since the immune response differs in these 3 groups, the use of IVIG could differentially modulate the immune response.
View Article and Find Full Text PDFArticle Synopsis
- * Interestingly, higher levels of certain cytokines (like IL-1, IL-6) were found in mild COVID-19 patients, along with significant cell damage in both mild and severe cases, contrasting with uninfected individuals.
- * The study highlights that mild cases show elevated levels of both pro-inflammatory and anti-inflammatory cytokines, which may link to stronger IgM and IgG antibody production, and emphasizes the need to understand the cytotoxic effects of SARS-CoV-2 on the oral mucosa.
Background And Objective: Little information is available on how to assess the impact of research studies conducted in government hospitals in Latin America and specifically in Mexico. We aimed to determine the returns on investment of the research projects that were carried out in the Hospital General "Dr. Manuel Gea Gonzalez" (HGMGG), a general university hospital located in Mexico City, using a categorization model.
View Article and Find Full Text PDF