Publications by authors named "A Fleig"
TRPM7 contributes to pyroptosis and its involvement in status epilepticus.
J Neuroinflammation
December 2024
Article Synopsis
- The study investigates pyroptosis, a form of programmed cell death, in the context of status epilepticus (SE), a condition marked by prolonged seizures, and how it relates to neurodegeneration.
- Researchers induced SE in mice using pilocarpine and found increased levels of inflammatory markers and TRPM7 expression, identifying TRPM7 as a key player in neuronal damage and hyperexcitability.
- The findings suggest that targeting TRPM7 and NLRP3 could be a potential treatment strategy for SE, as inhibiting these pathways alleviated neuronal hyperexcitability and pyroptosis.
Article Synopsis
- Researchers used genetically engineered mice and cell lines to study how the depletion of endoplasmic reticulum (ER) calcium stores activates specific calcium entry channels (SOCE) that primarily rely on Orai1 molecules.
- They discovered that Orai1 is the dominant calcium entry pathway compared to Orai2 and Orai3, and this process does not require functional TRPC molecules, as shown by experiments using cells with inactive TRPC genes.
- The study also found that even though the TRPC genes were disrupted, both store-depletion-activated calcium entry and receptor-operated calcium entry (ROCE) still relied on Orai1, leading to the establishment of a new strain of mice called TRPC heptaKO mice, which are
Article Synopsis
- *Global knockout of TRPM7 leads to embryonic lethality, emphasizing its importance in processes like embryogenesis, neural development, and learning and memory.
- *Research suggests that TRPM7 is linked to neurodegenerative diseases such as Alzheimer's and Parkinson's, making it a potential target for developing therapies aimed at CNS injuries and regenerative medicine.*
Waixenicin A, a xenicane diterpene from the octocoral , is a selective, potent inhibitor of the TRPM7 ion channel. To study the structure-activity relationship (SAR) of waixenicin A, we isolated and assayed related diterpenes from . In addition to known waixenicins A () and B (), we purified six xenicane diterpenes, 7,8-epoxywaixenicins A () and B (), 12-deacetylwaixenicin A (), waixenicin E (), waixenicin F (), and 20-acetoxyxeniafaraunol B ().
View Article and Find Full Text PDFObjective: The purpose of this study is to examine vocal fatigue and impairment, gastroesophageal symptoms, dysphagia risk, and sleep-related quality of life in individuals with obstructive sleep apnea (OSA) who have been treated with continuous positive airway pressure (CPAP) compared to those who have not received treatment.
Methods: Fifty-four participants diagnosed with OSA completed an online research form. Of these, 29 were receiving CPAP treatment, while 25 were not undergoing treatment.