Publications by authors named "A Flaczyk"
Developing new adjuvants/vaccines and better understanding their mode-of-action is an important task. To specifically improve birch pollen allergy treatment, we designed a fusion protein consisting of major birch pollen allergen Betv1 conjugated to the TLR5-ligand flagellin (rFlaA:Betv1). This study investigates the immune-modulatory effects of rFlaA:Betv1 on airway epithelial cells.
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- Postoperative delirium (POD) is a common condition after cardiac surgery, and this study aimed to identify specific proteins in the blood that change during surgery and may be linked to POD.
- Blood samples were collected from 16 patients before and after surgery, and advanced techniques were used to analyze over 1,300 proteins, revealing significant physiological changes in nearly half of them.
- Results showed that many proteins related to immune response and metabolism, especially interleukin-6, were elevated in patients with POD, highlighting a connection between surgical stress and altered mental states post-surgery.
Critically ill patients with COVID-19 are at increased risk for thrombotic complications which has led to an intense debate surrounding their anticoagulation management. In the absence of data from randomized controlled clinical trials, a number of consensus guidelines and recommendations have been published to facilitate clinical decision-making on this issue. However, substantive differences exist between these guidelines which can be difficult for clinicians.
View Article and Find Full Text PDFBackground: TLR ligands can promote Th1-biased immune responses, mimicking potent stimuli of viruses and bacteria.
Aim: To investigate the adjuvant properties of dual TLR2/7 ligands compared to those of the mixture of both single ligands.
Methods: Dual TLR2/7 ligands: CL401, CL413, and CL531, including CL264 (TLR7-ligand) and PamCysK (TLR2-ligand), were used.