Publications by authors named "A Fingerle"
Background: Dark-field chest radiography allows the assessment of the structural integrity of the alveoli by exploiting the wave properties of x-rays.
Purpose: To compare the qualitative and quantitative features of dark-field chest radiography in patients with COVID-19 pneumonia with conventional CT imaging.
Materials And Methods: In this prospective study conducted from May 2020 to December 2020, patients aged at least 18 years who underwent chest CT for clinically suspected COVID-19 infection were screened for participation.
Background: Dark-field radiography has been proven to be a promising tool for the assessment of various lung diseases.
Purpose: To evaluate the potential of dose reduction in dark-field chest radiography for the detection of the Coronavirus SARS-CoV-2 (COVID-19) pneumonia.
Materials And Methods: Patients aged at least 18 years with a medically indicated chest computed tomography scan (CT scan) were screened for participation in a prospective study between October 2018 and December 2020.
Article Synopsis
- HPV8, a type of human papillomavirus linked to skin cancer, affects immune cell presence and inflammation in patients with epidermodysplasia verruciformis (EV).
- The study found that HPV8 E6 significantly induces the chemokine CCL2, attracting monocytes and leading to a predominance of macrophages in the lesions, surpassing even pro-inflammatory cytokines like TNF-α.
- Researchers highlighted a specific mechanism involving the C/EBPα/miR-203/p63 pathway in how HPV8 E6 influences CCL2 production, showing that HPV8's oncoproteins disrupt skin immune balance for viral persistence.
Purpose: Evaluation of dual-layer spectral computed tomography (CT) for contrast enhancement during image-guided biopsy of liver lesions using virtual monoenergetic images (VMI) and virtual non-contrast (VNC) images.
Methods: Spectral CT data of 20 patients receiving CT-guided needle biopsy of focal liver lesions were used to generate VMI at energy levels from 40 to 200 keV and VNC images. Images were analyzed objectively regarding contrast-to-noise ratio between lesion center (CNR) or periphery (CNR) and normal liver parenchyma.
Grating-based X-ray phase-contrast and in particular dark-field radiography are promising new imaging modalities for medical applications. Currently, the potential advantage of dark-field imaging in early-stage diagnosis of pulmonary diseases in humans is being investigated. These studies make use of a comparatively large scanning interferometer at short acquisition times, which comes at the expense of a significantly reduced mechanical stability as compared to tabletop laboratory setups.
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