Publications by authors named "A Filip"
Multipath Projection Stereolithography for Three-Dimensional Printing Microfluidic Devices.
ACS Appl Mater Interfaces
December 2024
Although many lab-on-chip applications require inch-sized devices with microscale feature resolution, achieving this via current 3D printing methods remains challenging due to inherent trade-offs between print resolution, design complexity, and build sizes. Inspired by microscopes that can switch objectives to achieve multiscale imaging, we report a new optical printer coined multipath projection stereolithography (MPS) specifically designed for printing microfluidic devices. MPS is designed to switch between high-resolution (1× mode, ∼10 μm) and low-resolution (3× mode, ∼30 μm) optical paths to generate centimeter-sized constructs (3 × 6 cm) with a feature resolution of ∼10 μm.
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- Breast cancer is the most prevalent cancer in women, affecting over 2 million annually and leading to 650,000 deaths, but its epigenetic factors are still not fully understood.
- The study used data from The Cancer Genome Atlas and various omics datasets to identify significant features related to breast cancer, narrowing down from 417,486 to 2,701 relevant markers using advanced analytics methods.
- Findings revealed that cancer samples exhibited lower gene expression and higher methylation values, with potential regulatory mechanisms involving transcription factors and 3D chromatin structure, indicating fruitful avenues for new biomarkers and treatments.
Distal radioulnar joint (DRUJ) instability is a complex condition that can severely affect forearm function, causing pain, limited range of motion, and reduced strength. This review aims to consolidate current knowledge on the diagnosis and management of DRUJ instability, emphasizing a new classification system that we propose. The review synthesizes anatomical and biomechanical factors essential for DRUJ stability, focusing on the interrelationship between the bones and surrounding soft tissues.
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- Type 2 diabetes mellitus (T2DM) affects around 10% of adults worldwide and can complicate the risk of conditions like gastrointestinal bleeding and cancer.
- In a study of 633 endoscopic patients, those with T2DM had lower instances of epigastric pain and heartburn, but showed significantly higher rates of anemia and lower hemoglobin and serum iron levels.
- The results suggest that while T2DM is linked to increased gastritis and certain risks, it appears to have an inverse relationship with gastroesophageal reflux symptoms, and smoking further elevates the risk of infection.
Doxorubicin (DOX) is an effective anticancer drug, but its use is limited by dose-dependent heart toxicity. Quercetin is a natural antioxidant frequently studied for its beneficial properties. Moreover, a wide range of dietary supplements are available for human use.
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