Enhanced performance of gelatin 5-fluorouracil-containing nanoparticles against squamous cell carcinoma in simulated chronic wounds conditions.

Chronic wounds are considered a silent epidemic affecting a significant fraction of the World population. Their treatment supposes a large fraction of the public spending on the health of developed countries. In chronic wounds secondary to burns, trauma, UV light radiation, and diabetes, among others, the development of squamous cell carcinoma (SCC) has been reported.

[Effect of alloxan in pancreatectomized rats (author's transl)].

Sensitivty to alloxan of pancreatectomized rats is studied injecting on the seventh day after surgical resection with different dose of monohydrated alloxan. Totally pancreatectomized rats develop a strong diabetes just the same as the control group, but the former present higher glycemias and longer survival.

[Effect of insulin on germination and ionic exchange in Raphanus sativus (author's transl)].

Hypoglycemic sulfamide BZ-55 activates or inhibits germination of Raphanus sativus, depending upon the dosis. Since this drug acts upon the glycemia by increasing the secretion and action of insulin, the influence of this hormone on germination and ionic changes (Na+-K+) between seeds and culture medium, were studied. Seeds were incubated during 72 h with different concentrations of insulin in 10 ml deionized water or in 10 ml 18 mM K+ (KCl) solutions at 37 degrees C in vapor saturated atmosphere.