Publications by authors named "A Ferreira-gonzalez"
Next-generation sequencing (NGS) of solid tumors can inform treatment decisions; however, uptake remains low. This objective of this systematic review was to identify barriers to and facilitators of NGS in US oncology settings. Embase and MEDLINE were searched in March 2023 for articles published from 2012 to 2023 on barriers and facilitators of NGS adoption for solid tumors.
View Article and Find Full Text PDFThere are limited data on the prevalence of next-generation sequencing (NGS) in the United States, especially in light of the increasing importance of identifying actionable oncogenic variants due to molecular biomarker-based therapy approvals. This retrospective study of adult patients with select metastatic solid tumors and central nervous system tumors from the Optum Clinformatics Data Mart US health care claims database (January 1, 2014, to June 30, 2021; N = 63,209) examined NGS use trends over time. A modest increase in NGS was observed across tumor types from 2015 (0.
View Article and Find Full Text PDFArticle Synopsis
- Breast cancer is the leading cause of cancer deaths in women, with estrogen receptor positive (ER+) being the most common subtype.
- Improved survival rates for ER+ breast cancer patients are largely thanks to antiestrogen treatments like tamoxifen, but about 30% of patients face recurrence and treatment resistance.
- This study identifies two new combination therapies (simeprevir and VX-680) that, when paired with tamoxifen, significantly lower tumor levels in animal models and could enhance the effectiveness of tamoxifen in treating ER+ breast cancer.
Article Synopsis
- Basal-like triple-negative breast cancer (TNBC) is tough to treat because of its resistance mechanisms, but it typically has a highly active PI3K pathway instead of PIK3CA mutations.
- BYL-719, a PIK3CA inhibitor with minimal drug interactions, has shown promise in combination therapies, particularly in cases where other treatments have failed.
- Research using patient-derived xenografts identified effective drug combinations involving BYL-719 and other compounds, suggesting a new treatment approach for cancers driven by PIK3CA and related pathways.
Graft-versus-host disease is an uncommon complication of solid-organ transplant and is associated with a high rate of mortality. Here, we describe a female patient with primary biliary cholangitis who developed graft-versus-host disease following an orthotopic liver and renal allotransplant from a deceased male donor. Systemic donor lymphoid chimerism is one of several important findings to confirm a diagnosis of graft-versus-host disease after solid-organ transplant, along with clinical and histologic findings.
View Article and Find Full Text PDF