Publications by authors named "A Fernandez Centeno"

Article Synopsis
  • Researchers are exploring new ways to enhance interactions between cells and the extracellular matrix (ECM) to improve kidney organoid development from human pluripotent stem cells (hPSCs).
  • They created renal decellularized ECM (dECM) hydrogels from porcine and human kidney tissue, which support more effective kidney differentiation and the formation of blood vessel features in organoids.
  • This study establishes a method to generate kidney organoids with vascular-like structures, demonstrating the potential for these improved culture systems in advancing personalized medicine applications.
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Regulated deficit irrigation (RDI) strategies aim to improve water usage without reducing yield. Generally, irrigation strategy effectiveness is measured as fruit yield, with little consideration of fruit quality. As water deficit and increased plant cell sclerification are often associated, this study explored the effect of RDI on pear fruit stone cells, a crucial trait affecting flesh texture.

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Objective:  Pregnancy in women with lupus poses a higher risk of complications compared with the general population. The present study aimed to determine and describe the obstetric and neonatal outcomes of pregnant women with lupus.

Materials And Methods:  We conducted an observational retrospective study of pregnant women with the diagnosis of lupus, who were selected and followed at the Maternal-Fetal Medicine Clinic of our institution between January 2013 and July 2018.

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The reliability of analysis is becoming increasingly important as point-of-care diagnostics are transitioning from single-analyte detection toward multiplexed multianalyte detection. Multianalyte detection benefits greatly from complementary metal-oxide semiconductor (CMOS) integrated sensing solutions, offering miniaturized multiplexed sensing arrays with integrated readout electronics and extremely large sensor counts. The development of CMOS back end of line integration compatible graphene field-effect transistor (GFET)-based biosensing has been rapid during the past few years, in terms of both the fabrication scale-up and functionalization toward biorecognition from real sample matrices.

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Article Synopsis
  • - The study focuses on determining how the time between completing neoadjuvant therapy (NAT) and undergoing total mesorectal excision (TME) affects outcomes in patients with extraperitoneal locally advanced rectal cancer (LARC), hypothesizing that longer intervals might increase pathologic complete response (pCR) rates without raising surgical risks.
  • - Researchers analyzed data from 1,506 LARC patients across six centers, categorizing them into groups based on whether the interval between NAT and surgery was short (≤8 weeks), intermediate (>8 and ≤12 weeks), or long (>12 weeks), with a median follow-up of 33 months.
  • - Results showed that the overall pCR rate was 17.
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