Publications by authors named "A Ferencz"
Background/objectives: Type 1 diabetes affects cytokines as potential inducers of NFκB signalling involved in inflammation and neuronal survival. Our goal was to assess the expression of NFκB p65 and its negative regulator, Nrf2, in myenteric neurons and adjacent smooth muscle of different gut segments after chronic hyperglycaemia and immediate insulin treatment.
Methods: After ten weeks of hyperglycaemia, intestinal samples of control, streptozotocin-induced diabetic and insulin-treated diabetic rats were prepared for fluorescent immunohistochemistry, immunogold electron microscopy, ELISA and qPCR.
Article Synopsis
- The study investigates the effectiveness of high-power short-duration (90 W/4 s) radiofrequency ablation for pulmonary vein isolation (PVI) in patients with atrial fibrillation, particularly looking at gaps in ablation lines that can lead to recurrences.
- Using data from 20 patients and analyzing 1,357 ablation points, the researchers identified key factors affecting the occurrence of these gaps, including interlesion distance (ILD) and generator impedance.
- The findings suggest that smaller ILDs (3.5 mm anteriorly and 4 mm posteriorly) improve the durability of PVI, indicating that adjustments in ablation techniques might be necessary compared to traditional approaches.
Simulators are widely used in medical education, but objective and automatic assessment is not feasible with low-fidelity simulators, which can be solved with artificial intelligence (AI) and virtual reality (VR) solutions. The effectiveness of a custom-made VR simulator and an AI-based evaluator of a laparoscopic peg transfer exercise was investigated. Sixty medical students were involved in a single-blinded randomised controlled study to compare the VR simulator with the traditional box trainer.
View Article and Find Full Text PDFNeurodegenerative diseases affect an increasing part of the population of modern societies, burdening healthcare systems and causing immense suffering at the personal level. The pathogenesis of several of these disorders involves dysregulation of gene expression, which depends on several molecular processes ranging from transcription to protein stability. microRNAs (miRNAs) are short non-coding RNA molecules that modulate gene expression by suppressing the translation of partially complementary mRNAs.
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