Per aspera ad astra: application of Simplex QSAR approach in antiviral research.

This review explores the application of the Simplex representation of molecular structure (SiRMS) QSAR approach in antiviral research. We provide an introduction to and description of SiRMS, its application in antiviral research and future directions of development of the Simplex approach and the whole QSAR field. In the Simplex approach every molecule is represented as a system of different simplexes (tetratomic fragments with fixed composition, structure, chirality and symmetry).

6-azacytidine--compound with wide spectrum of antiviral activity.

6-azacytidine demonstrates activity against adenoviruses types 1, 2, 5. It inhibit synthesis of viral DNA and proteins. 6-AC shows antiherpetic and antiinfluenza action during experimental infection in mice.

[Participation of the proteolysis system in promoting the virulence of the influenza virus and development of the infectious process; the antiviral effect of protease inhibitors].

The results of the authors' own studies and data from the literature attesting to an important role of proteolytic mechanisms in influenza virus physiology and the development of the infectious process are summarized. The etiotropic and pathogenetic effectiveness of proteolysis inhibitors in influenza was demonstrated experimentally and clinically. Data are presented on the immunostimulating and prophylactic effect of a proteolysis inhibitor, E-aminocaproic acid.

[Proteolysis intensification during influenza virus interaction with plasma membrane of sensitive cells].

The possibility of the proteolotic enzymes incorporation into the viral particle and the changes in proteolysis during interaction of the purified influenza virus (A2 Hong-Kong (1)68) with isolated plasmatic membranes of the mice lungs were studied. The presence of trypsin-like protease in the purified influenza virion was found. It is established that proteolysis intensifies during a short-term interaction of the isolated plasmatic membranes with the influenza virus.