Publications by authors named "A Fawad Jebran"
Background: Alterations in the buffering of intracellular Ca, for which myofilament proteins play a key role, have been shown to promote cardiac arrhythmia. It is interesting that although studies report atrial myofibrillar degradation in patients with persistent atrial fibrillation (persAF), the intracellular Ca buffering profile in persAF remains obscure. Therefore, we aimed to investigate the intracellular buffering of Ca and its potential arrhythmogenic role in persAF.
View Article and Find Full Text PDFThe German Centre for Cardiovascular Research (DZHK) is one of the German Centres for Health Research and aims to conduct early and guideline-relevant studies to develop new therapies and diagnostics that impact the lives of people with cardiovascular disease. Therefore, DZHK members designed a collaboratively organised and integrated research platform connecting all sites and partners. The overarching objectives of the research platform are the standardisation of prospective data and biological sample collections among all studies and the development of a sustainable centrally standardised storage in compliance with general legal regulations and the FAIR principles.
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- Actively triggerable materials can provide better control over the lifespan of biomedical technologies but often lack durability; traditional choices like polymers have limitations compared to stronger metals.
- Metals, specifically using a method called liquid metal embrittlement, can be engineered to break down under certain conditions; this involves liquid metals weakening solid metals at their grain boundaries.
- The study showcases eutectic gallium indium (EGaIn), a biocompatible metal alloy that effectively triggers the breakdown of aluminum in relevant biological settings, and discusses three potential applications for these actively triggerable metals in biomedical devices.
Engineered heart muscle (EHM) can be implanted epicardially to remuscularize the failing heart. In case of a severely scarred ventricle, excision of scar followed by transmural heart wall replacement may be a more desirable application. Accordingly, we tested the hypothesis that allograft (rat) and xenograft (human) EHM can also be administered as transmural heart wall replacement in a heterotopic, volume-loaded heart transplantation model.
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- * The new device utilizes knotted pressure sensors made with liquid metal-infused silicone, mimicking ancient Andean quipu for data transmission.
- * Testing showed that the device's performance is comparable to commercial manometers, potentially making GI motility assessment more accessible in resource-limited environments.