Publications by authors named "A Faura"

Article Synopsis
  • Loss of B-cell aplasia (BCA) is linked to the effectiveness of CD19 CAR-T therapy for B-cell acute lymphoblastic leukemia, with most relapses occurring in the first months post-infusion, particularly in patients with high tumor burden (HTB).
  • A study of 73 patients showed that those with HTB had significantly lower event-free survival (EFS) rates (19.3%) compared to those with low tumor burden (LTB) (67.2%), and relapses were more likely to be CD19-negative in the HTB group.
  • The findings suggest that BCA loss is associated with a higher risk of CD19-positive relapses and that patients with HTB might benefit from additional
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Introduction: Chimeric antigen receptor (CAR)T-cell CD19 therapy is an effective treatment for relapsed/refractory B-cell acute lymphoblastic leukemia. It can be associated with life-threatening toxicities which often require PICU admission. Purpose: to describe clinical characteristics, treatment and outcome of these patients.

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Health-related quality of life (HRQOL) improves after kidney transplantation (KT) but declines over time. Studies on the effect of early postoperative basal insulin therapy on HRQOL after KT, especially KTRs at high risk of developing post-transplant diabetes mellitus (PTDM) are missing. Data from a randomized controlled trial on 148 non-diabetic KTRs were analyzed.

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Malnutrition has a negative impact on patients with chronic diseases and its early identification is a priority. The primary objective of this diagnostic accuracy study was to assess the performance of the phase angle (PhA), a bioimpedance analysis (BIA)-derived parameter, for malnutrition screening using the Global Leadership Initiative for Malnutrition (GLIM) criteria as the reference standard in patients with advanced chronic kidney disease (CKD) waiting for kidney transplantation (KT); criteria associated with low PhA in this population were also analyzed. Sensitivity, specificity, accuracy, positive and negative likelihood ratios, predictive values, and area under the receiver operating characteristic curve were calculated for PhA (index test) and compared with GLIM criteria (reference standard).

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