Publications by authors named "A Faulstich"
Article Synopsis
- The study examined how albumin and immunoglobulin G (IgG) enter cerebrospinal fluid (CSF) and identified variations in their permeability in patients.
- Using a retrospective analysis of CSF samples, researchers found altered IgGIndices in nearly 39% of patients, indicating significant differences in how albumin and IgG permeate through the blood-brain barrier.
- The results suggest that albumin and IgG can be affected by different factors independently, providing a clearer understanding of protein exchange between blood and CSF under both pathological and normal conditions.
Background: Family and twin studies suggest predisposing genetic factors in stroke. Lacunar infarcts represent a homogeneous phenotype, which is a prerequisite for genetic analyses. Applying an affected sib -pair analysis, we prospectively assessed the prevalence of microangiopathic brain lesions (MBL) and associated risk factors among siblings of patients with lacunar stroke.
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- - The study aims to determine how factors like serum concentration and barrier permeability affect the levels of albumin and immunoglobulin G (IgG) in cerebrospinal fluid (CSF) from a sample of 1700 patients.
- - Findings indicate that, in patients with normal CSF albumin levels, barrier permeability and CSF flow have a much stronger influence on CSF concentrations than serum concentrations.
- - Notably, CSF flow is the most significant determinant, especially in cases of elevated CSF albumin levels, while understanding individual variations will require more precise measurements of CSF flow.
Objective: To illustrate the influence of cerebrospinal fluid (CSF) flow on lumbar CSF protein concentration and to test for an altered blood-CSF barrier permeability as additional influence.
Patients And Methods: Consecutively hospitalized patients with normotensive hydrocephalus (n = 21) underwent lumbar puncture with CSF being sampled in sequential portions. CSF/blood quotients of albumin (QAlb) and of immunoglobulin G (QIgG) were compared intra-individually and with calculated values from a reference patient sample.