Measurement of extracellular fluid carboplatin kinetics in melanoma metastases with microdialysis.

Clinical anti-tumour efficacy of anti-cancer drugs is a function of dose intensity, i.e. the concentration--time profile in tumour tissue.

The effect of hyperoxia and hypercapnia on fundus pulsations in the macular and optic disc region in healthy young men.

The purpose of this study was to investigate the influence of hyperoxia and hypercapnia on fundus pulsations in the macular and optic disc region and determine a potential autoregulative capacity of the choroid under these conditions. In a randomized cross-over study 100% O2 and a mixture of 5% CO2 with air was inhaled for 10 min by ten healthy male volunteers on different study days. Fundus pulsations were measured with a recently described laser interferometer.

Key metabolite kinetics in human skeletal muscle during ischaemia and reperfusion: measurement by microdialysis.

The tissue kinetics of key metabolites of ischaemic and postischaemic tissue damage were studied in the intercellular space of human skeletal muscle by microdialysis. In vivo microdialysis calibration experiments (n = 5) yielded the basal intercellular concentration of glucose in human skeletal muscle (3.6 +/- 0.

Studies on the neutralizing effects of protamine on unfractionated and low molecular weight heparin (Fragmin) at the site of activation of the coagulation system in man.

In a double-blind, randomized, cross-over study the neutralizing action of protamine towards unfractionated heparin (UFH, 150 U/kg i.v.) and a low molecular weight heparin (LMWH, Fragmin, 100 anti-Xa U/kg i.

[Blind nasotracheal intubation in the muscle-relaxed patient].

A modified method of blind nasal intubation, using a muscle relaxant, is described, which has been used in 100 patients with an efficacy of 96%. The risk of suboxygenation was overcome by withdrawing the tube to the epipharynx and ventilating the patient's lungs after each failure to insert the tube in the trachea. The blind nasotracheal intubation of a relaxed patient is to be considered, when orotracheal intubation will be difficult or impossible to achieve, because of anatomic abnormalities or pathologic conditions of the upper respiratory tract.