Publications by authors named "A Farrar"
Introduction: Clinical research faces the challenge of declining physician participation in the pursuit of advancing evidence-based medicine. This secondary analysis focuses on the interactive mobile health (mHealth) application's utility as a real-time data collection tool in clinical settings, specifically targeting cow's milk protein allergy (CMPA) management. The study assesses the mHealth application's potential to alleviate data collection inefficiencies and improve physician engagement in clinical research.
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- KSHV is linked to cancers in HIV patients, like Kaposi's sarcoma and primary effusion lymphoma (PEL), and the oncogene MCL1 helps these cancer cells resist apoptosis and chemotherapy.
- Researchers found a surprising relationship between MCL1 and the protein MARCHF5, showing they work together to help PEL cells survive by regulating apoptosis, despite MARCHF5 not being directly known for this function.
- The study reveals that MARCHF5 helps to degrade NOXA, a pro-apoptotic signal, thus boosting MCL1's survival role in PEL cells, indicating potential new strategies for developing combination therapies against KSHV-related cancers.
Article Synopsis
- The study showcases a new technology, Adaptive Channel Bacterial Capture (ACBC), which effectively captures, enriches, and identifies bacterial pathogens from low-density samples with nearly perfect efficiency.
- This method uses simple fabrication techniques and can capture various bacteria, including common pathogens, even when present in concentrations below 1000 cells per mL.
- The ACBC device can also quickly determine antibiotic susceptibility of identified bacteria using fluorescence imaging and machine learning techniques, combining bacterial capture and rapid testing in a single tool.
Objective: Mindfulness-based interventions are increasingly being used in schools to improve students' mental, emotional, and behavioral development. Although many mindfulness programs exist, the types of programs that are effective for specific age groups remain unclear. In this systematic review, the authors used established rating criteria to describe the level of evidence for school-based mindfulness interventions.
View Article and Find Full Text PDFAntibiotic resistance is an urgent global health challenge, necessitating rapid diagnostic tools to combat its threat. This study uses citizen science and image feature analysis to profile the cellular features associated with antibiotic resistance in Escherichia coli. Between February and April 2023, we conducted the Infection Inspection project, in which 5273 volunteers made 1,045,199 classifications of single-cell images from five E.
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