Publications by authors named "A Fares"
Background: The increasing prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), parallels the rise in sedentary lifestyles. MASLD is the most common form of steatotic liver disease (SLD), which represents the umbrella beneath which the vast majority of chronic liver diseases fall, including alcohol-related liver disease and their overlap. These conditions are the leading contributors to chronic liver disease, significantly impacting global morbidity and mortality.
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- Clinical guidelines recommend using buffered crystalloid solutions for critically ill patients, but do not specify which type, prompting a survey of physicians' preferences between acetate- and lactate-buffered solutions.* -
- An international survey of 1321 anesthesiologists and ICU physicians found that the majority used these solutions frequently, with varying availability of both types across different countries.* -
- Most physicians supported a randomized trial comparing the two solutions, rating its clinical importance as significant, but not urgent, with a median score of 5 out of 9.*
Article Synopsis
- - This study examines whether lower doses of anti-PD(L)1 agents are as effective as the standard doses for treating patients with solid tumors at a Brazilian hospital, aiming to highlight cost-effectiveness.
- - A total of 71 patients were analyzed, comparing efficacy outcomes such as clinical overall response rate, progression-free survival, and overall survival between those receiving low-dose (LD) and conventional-dose (CD) treatments.
- - Findings revealed no significant differences in treatment outcomes between LD and CD groups, suggesting that lower doses could provide a more accessible treatment option worth further investigation in future randomized trials.
Amazon streams impacted by bauxite mining present distinct local contributions to the beta diversity of aquatic insects, fish, and macrophytes.
Sci Total Environ
December 2024
Integrating the physicochemical characteristics of aquatic environments with their biotas is essential for the conservation and monitoring of biodiversity, given the sensitivity of both the biotic and the abiotic components to environmental changes linked to water quality and human activities. In the present study, we evaluate how the contributions of different taxa to beta diversity, through local and species effects, can indicate the priority sites for conservation and ecological restoration in an Amazon region impacted by bauxite mining. We also investigate how environmental conditions at local and landscape scales influence the beta diversity of the aquatic biota.
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- - The study analyzed 79 patients with severe tuberculosis-related ARDS who received ECMO treatment at 20 centers worldwide, focusing on their 90-day survival rates and related complications.
- - Results showed that 51% of patients survived for 90 days, with significant complications including major bleeding and infections; miliary TB patients had a notably higher survival rate than those with cavitary TB.
- - Factors like older age, drug-resistant TB, and higher pre-ECMO SOFA scores were identified as key predictors of mortality, suggesting that ECMO could be a valuable intervention for patients with TB-induced ARDS.