Publications by authors named "A Falqui"
Article Synopsis
- * Research shows that reducing ADAM10 levels in HD mouse models can reverse spine loss and synaptic issues in the hippocampus, demonstrating its role in maintaining synaptic integrity.
- * The study suggests that inhibiting ADAM10 alongside targeting the TrkB signaling pathway could be an effective strategy for preventing cognitive decline and enhancing synaptic function in HD.
Article Synopsis
- Huntington's disease (HD) leads to the degeneration of specific brain neurons, resulting in a mix of functional and dysfunctional cells, but the interactions between these cell types are not well understood.
- Researchers created brain organoids containing both healthy and HD cells, finding that HD organoids displayed neurodevelopmental issues and fewer GABAergic neurons compared to healthy ones.
- Healthy cells in mixed organoids helped to restore the identity and function of HD cells through direct interactions, suggesting that enhancing communication between different cell types could offer new treatment strategies for HD.
Polymers can serve as an effective matrix to stabilize gold nanoparticles. These materials offer a continuous light-activated supply of subnanoclusters, which are composed of a few atoms. We report an efficient approach to enhance the catalytic activity of gold subnanoclusters by feeding of these species through the generation of hot carriers 5d-6s6p interband transitions on PEG-stabilized Au nanoparticles.
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- * The research specifically investigates NP Au's effectiveness in degrading methyl orange (MO), a toxic dye, using various analytical techniques like UV-Vis absorption spectroscopy and high-performance liquid chromatography.
- * Results indicate that the primary function of NP Au is the rapid and reversible adsorption of MO, while the actual catalytic degradation of the dye occurs at a slower rate.
Oncogenic mutations accumulating in many chromatin-associated proteins have been identified in different tumor types. With a mutation rate from 10 to 57%, has been widely considered a tumor suppressor gene. However, whether this role is mainly due to its transcriptional-related activities or its ability to preserve genome integrity is still a matter of intense debate.
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