Publications by authors named "A Fallarero"
Article Synopsis
- The rise of multidrug-resistant bacteria and a lack of new antibiotics has spurred the need for more effective antibacterial treatments.
- Researchers developed a series of etrasimod derivatives and found that indole derivative 24f was the most powerful against resistant bacteria like MRSA, showing effective antibacterial properties and low toxicity.
- Importantly, 24f did not cause resistance in bacteria and demonstrated its effectiveness in an in vivo model, showcasing its potential as a significant antibacterial candidate.
Bacterial biofilms account for up to 80% of all infections and complicate successful therapies due to their intrinsic tolerance to antibiotics. Biofilms also cause serious problems in the industrial sectors, for instance due to the deterioration of metals or microbial contamination of products. Efforts are put in finding novel strategies in both avoiding and fighting biofilms.
View Article and Find Full Text PDFA series of quaternary ammonium fluoroquinolones was obtained by exhaustive methylation of the amine groups present at the 7-position of fluoroquinolones, including ciprofloxacin, enoxacin, gatifloxacin, lomefloxacin, and norfloxacin. The synthesized molecules were tested for their antibacterial and antibiofilm activities against Gram-positive and Gram-negative human pathogens, i.e.
View Article and Find Full Text PDFDisrupting bacterial quorum sensing (QS) signaling is a promising strategy to combat pathogenic biofilms without the development of antibiotic resistance. Here, we report that food-associated bacteria can interfere with the biofilm formation of a Gram-negative pathogenic bacterium by targeting its AHL (acyl-homoserine lactone) QS system. This was demonstrated by screening metabolic end-products of different lactobacilli and propionibacteria using Gram-negative and biofilm-forming as the QS reporter and our anti-QS microscale screening platform with necessary modifications.
View Article and Find Full Text PDFArticle Synopsis
- New antibiotics are urgently needed to combat drug-resistant bacteria, and drug repurposing may help speed up this process.
- The study identified etrasimod, an existing investigational drug for ulcerative colitis, as an effective antibacterial agent, particularly against Gram-positive bacteria, including resistant strains.
- Etrasimod not only exhibited strong bactericidal properties but also inhibited biofilm formation and showed potential for use in combination therapies without harming mammalian cells.