Publications by authors named "A Facoetti"
Purpose: Primary gynecological melanomas are uncommon with lower survival rates compared to cutaneous melanomas. Although melanocytes have been identified in a variety of mucosal membranes, little is known about their interactions or roles inside the mucosa layer. Melanin is a common pigment in nature and is endowed with several peculiar chemical, paramagnetic, and semiconductive characteristics.
View Article and Find Full Text PDFPurpose: There is debate about the optimal management of borderline resectable (bRe) and resectable (Re) pancreatic ductal adenocarcinoma (PDAC). Both preclinical and clinical evidence showed that carbon ion radiotherapy (CIRT) produces superior control on radioresistant histologies compared to conventional photon beam radiotherapy (RT). However, so far there is a lack of data concerning the integration of CIRT in a multimodal approach with chemotherapy and surgery for bRe/Re.
View Article and Find Full Text PDFNanodroplets have demonstrated potential for the range detection of hadron radiotherapies. Our formulation uses superheated perfluorobutane (C4F10) stabilized by a poly(vinyl-alcohol) shell. High-LET (linear energy transfer) particles vaporize the nanodroplets into echogenic microbubbles.
View Article and Find Full Text PDFCharged particle radiotherapy for thyroid cancer. A systematic review.
Crit Rev Oncol Hematol
October 2024
Article Synopsis
- The use of external beam radiotherapy (EBRT) for thyroid cancer treatment is debated because there isn't a lot of strong data.
- Some studies suggest that EBRT can help people with high-risk cases of thyroid cancer when it's used with surgery and chemotherapy.
- Newer treatments like proton therapy and Boron Neutron Capture Therapy (BNCT) could be helpful, but more research is needed to understand how they work best.
Article Synopsis
- Decellularized ECM bioscaffolds are being explored as a new 3D model for studying radiation effects on cancer cells, specifically radioresistant cell lines HMV-II and PANC-1.
- The study involved irradiating these cells in porcine liver-derived scaffolds with high- and low-energy radiation to evaluate their biological responses in a more realistic in vivo-like environment.
- Results showed that cells maintained their specific characteristics and responded differently to high LET radiation, with Carbon Ions causing more significant damage than photons, indicating that these bioscaffolds could be valuable for future radiobiological research.