Publications by authors named "A Fabrice Some"
Background: Two pre-erythrocytic vaccines (R21/Matrix-M and RTS,S/AS01) are now approved for Plasmodium falciparum malaria. However, neither induces blood-stage immunity against parasites that break through from the liver. RH5.
View Article and Find Full Text PDFFactors associated with positive human papillomavirus (HPV) test results in cervical precancer screening: a cross-sectional study at Souro Sanou National Teaching Hospital (SSNTH) in Bobo Dioulasso, Burkina Faso.
BMC Public Health
October 2024
Introduction: Human papilloma virus testing is a new method of screening for precancerous cervical lesions. Here we identified factors associated to the positive Human papilloma virus-testing in the context of cervical precancer screening at the Souro Sanou National Teaching Hospital in Burkina Faso.
Materials And Method: Conducted from June 2021-May 2022, this was a cross-sectional study, including patients aged between 25 and 55 years-old and screened for precancerous lesions and received HPV-testing at the Department of Gynecology, Obstetrics and Reproductive Medicine (DGORM) of the SSNTH.
Article Synopsis
- - The WHO recommends HPV testing for cervical cancer screening due to its high sensitivity, but further triage is needed to identify women with high-grade lesions (CIN2+) who need treatment.
- - The ANRS-12375 study evaluated various triage methods like visual inspection (VIA) and different genotyping options in Côte d'Ivoire, Burkina Faso, and Cambodia to detect CIN2+ lesions among women living with HIV.
- - Results showed that VIA and extended genotyping had high sensitivity (89%), with VIA also exhibiting the best specificity among the tests, making them effective options for identifying women who require treatment for CIN2+.
Impact of a package of point-of-care diagnostic tests, a clinical diagnostic algorithm and adherence training on antibiotic prescriptions for the management of non-severe acute febrile illness in primary health facilities during the COVID-19 pandemic in Burkina Faso.
BMC Infect Dis
August 2024
Article Synopsis
- The study aimed to evaluate the effectiveness of a new intervention for reducing antibiotic prescriptions and improving recovery rates in patients with non-severe acute febrile illnesses at primary health centers.
- Patients were divided into two groups: one received the intervention, which included point-of-care tests and a diagnostic algorithm, while the other received standard care.
- Results showed that the intervention significantly lowered antibiotic prescriptions (33.2% vs. 58.1%) and improved adherence to treatment, with all patients recovering by Day 7 regardless of the care received.
Historically has followed a pattern of drug resistance first appearing in low-transmission settings before spreading to high-transmission settings. Several features of low-transmission regions are hypothesized as explanations: higher chance of symptoms and treatment seeking, better treatment access, less within-host competition among clones and lower rates of recombination. Here, we test whether importation of drug-resistant parasites is more likely to lead to successful emergence and establishment in low-transmission or high-transmission periods of the same epidemiological setting, using a spatial, individual-based stochastic model of malaria and drug-resistance evolution calibrated for Burkina Faso.
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