Metastasis-directed stereotactic radiotherapy in patients with breast cancer: results of an international multicenter cohort study.

Metastasis-directed therapy (MDT) for oligometastatic breast cancer (≤ 5 metastases) has shown little effect in specific scenarios of randomized trials. Therefore, we aimed to assess outcomes after metastasis-directed stereotactic radiotherapy (SRT) in various clinical scenarios. We conducted an international retrospective cohort study in thirteen centers including breast cancer patients receiving SRT to any metastatic site.

Online Radiotherapy: The Paradigm Shift to Real-Time Adaptive Radiotherapy.

Background: Adaptive radiotherapy (ART) involves the continuous adaptation of the radiation plan according to patient- and tumor-specific feedback. In online ART, the plan is optimized in real time during the treatment; in offline ART, the plan is recalculated between treatment sessions. Hybrid linear accelerators with integrated CT, MRI, or PET are required to perform online ART.

Spectroscopic Study of Strain, Oxidation, and Formation of Few-Layer Graphene at Steel Surfaces Tribologically Tested against MoS Films.

MoS not only has unique optoelectronic properties realizing photonic and semiconductor applications but also serves as a promising solid lubricant in tribological three-body contacts due to its advantageous friction and wear behavior. Its functionality is defined by elementary processes including strain, oxidation processes, and material mixing. However, these mechanisms were not elucidated for MoS having transferred from the MoS film synthesized at the main body to a steel counter body during tribological ball-on-disk tests.

Re-evaluation of the prospective risk analysis for artificial-intelligence driven cone beam computed tomography-based online adaptive radiotherapy after one year of clinical experience.

Cone-beam computed tomography (CBCT)-based online adaptation is increasingly being introduced into many clinics. Upon implementation of a new treatment technique, a prospective risk analysis is required and enhances workflow safety. We conducted a risk analysis using Failure Mode and Effects Analysis (FMEA) upon the introduction of an online adaptive treatment programme (Wegener et al.