Publications by authors named "A F W van der Steeg"
Article Synopsis
- This study investigates the effectiveness of highly-conformal image-guided radiotherapy (IGRT) for patients with high-risk neuroblastoma (HR-NBL), focusing on locoregional control outcomes.
- The research involved 77 patients treated between 2015-2022, analyzing various factors such as the size of residual lesions and their impact on locoregional failure rates.
- Results showed a low five-year locoregional failure rate of 7.8%, indicating that IGRT with reduced margins and dose boosts for larger residual lesions is effective in managing HR-NBL.
Objectives: The International Society of Paediatric Oncology-Renal Tumour Study Group (SIOP-RTSG) discourages invasive procedures to determine the histology of paediatric renal neoplasms at diagnosis. Therefore, the histological subtype of Wilms' tumours (WT) is unknown at the start of neoadjuvant chemotherapy. MR-DWI shows potential value as a non-invasive biomarker through apparent diffusion coefficients (ADCs).
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- - The study explored the effectiveness of taurolidine-citrate(-heparin) lock solutions (TCHL) in preventing central-line-associated bloodstream infections (CLABSI) in pediatric oncology patients, with a trial conducted from 2020 to 2023.
- - A total of 462 patients using central venous access devices were split into two groups: one using TCHL and the other using heparin-only locks (HL), with follow-ups for 90 days post-insertion.
- - Results showed no significant difference in the incidence of CLABSI between the TCHL and HL groups, with slightly fewer infections in the TCHL group, but adverse events occurred more often in that group.
A systematic review on safety and surgical and anesthetic risks of elective abdominal laparoscopic surgery in infants to guide laparoscopic ovarian tissue harvest for fertility preservation for infants facing gonadotoxic treatment.
Front Oncol
May 2024
Background: Infertility is an important late effect of childhood cancer treatment. Ovarian tissue cryopreservation (OTC) is established as a safe procedure to preserve gonadal tissue in (pre)pubertal girls with cancer at high risk for infertility. However, it is unclear whether elective laparoscopic OTC can also be performed safely in infants <1 year with cancer.
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- Achieving complete tumor removal is difficult, but can be enhanced using real-time fluorescence-guided surgery with specially designed molecular probes.
- The traditional process of identifying and testing these probes is lengthy and complicated by the variation within tumors and between different patients.
- To address these challenges, researchers created a multispectral real-time 3D imaging platform that uses organoid technology to better mimic the diversity in patient tumors and how probes bind to healthy tissue.