Publications by authors named "A F Talento"
Objectives: To determine the percentage of patients across Ireland who are discharged from the Emergency Department (ED) with an antimicrobial prescription, the indication, classification of infections, and guideline compliance. To identify potential areas for antimicrobial stewardship (AMS) interventions in the ED.
Patients And Methods: A multicentre, prospective cohort analysis study in EDs across eight hospitals in Ireland.
Article Synopsis
- CAPA, or COVID-19-associated pulmonary aspergillosis, occurs in patients with severe SARS-CoV-2 infections and has a high mortality rate of about 50%, complicated by azole resistance.
- A genomic analysis of 21 CAPA isolates from four European countries revealed a 14.3% prevalence of azole resistance, all linked to known genetic mutations.
- The findings suggest that monitoring for resistant strains and potentially updating antifungal treatment guidelines could improve patient outcomes among those suspected of having CAPA.
Predictors for Prolonged Hospital Stay Solely to Complete Intravenous Antifungal Treatment in Patients with Candidemia: Results from the ECMM Candida III Multinational European Observational Cohort Study.
Mycopathologia
December 2023
Background: To date, azoles represent the only viable option for oral treatment of invasive Candida infections, while rates of azole resistance among non-albicans Candida spp. continue to increase. The objective of this sub-analysis of the European multicenter observational cohort study Candida III was to describe demographical and clinical characteristics of the cohort requiring prolonged hospitalization solely to complete intravenous (iv) antifungal treatment (AF Tx).
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- The study aimed to evaluate the distribution of Candida species and their antifungal resistance in cases of candidaemia across Europe, analyzing data collected from 41 centers in 17 countries between 2018 and 2022.
- The most common isolates identified were C. albicans, C. glabrata, and C. parapsilosis, with notable geographical variations in their prevalence and antifungal resistance patterns.
- Resistance to fluconazole was observed in certain species, particularly C. glabrata and C. parapsilosis, with rare cases of echinocandin resistance found, including specific genetic mutations in resistant isolates.
Beyond consumption: a qualitative investigation of hospital clinician attitudes to receiving feedback on antimicrobial prescribing quality.
Antimicrob Steward Healthc Epidemiol
April 2022
Background: Feedback on optimal antimicrobial prescribing to clinicians is an important strategy to ensure antimicrobial stewardship (AMS) in the hospital setting.
Objective: To explore the perceptions of antimicrobial prescribing feedback among clinicians in acute care.
Study Design: Prospective qualitative design.