Publications by authors named "A F Smirnov"

The number of permanent average annual rural population in the Russian Federation is declining and over 2013-2022 decreased from 37.2 to 36.9 million people.

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Neutrophils are the most abundant cell type in the airways of tuberculosis patients. Mycobacterium tuberculosis (Mtb) infection induces the release of neutrophil extracellular traps (NETs); however, the molecular regulation and impact of NET release on Mtb pathogenesis are unknown. We find that during Mtb infection in neutrophils, PAD4 citrullinates histones to decondense chromatin that gets released as NETs in a manner that can maintain neutrophil viability and promote Mtb replication.

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Efficient second harmonic generation and broad-band photoluminescence from deeply subwavelength and nontoxic nanoparticles is essential for nanophotonic applications. Here, we explore nonlinear optical response from mesoporous Si/SiO, SiO, and Si nanoparticles, considering various fabrication and treatment procedures. We show that thermal annealing (including femtosecond laser treatment) of mesoporous Si/SiO nanoparticles provides the transformation of Si phase from amorphous to crystalline, enhancing the second harmonic and nonlinear photoluminescent response.

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One of the key factors in manufacturing products by fused deposition molding (FDM) or layer-by-layer printing technology is the material intensity of the product. The task of reducing the amount of material required to manufacture a product without significant loss of mechanical properties is one of the most practically important technological tasks. Material saving in FDM printing of products allows to reduce financial costs and increase the speed of manufacturing of the final product without reducing (or not significantly reducing) the quality properties of the product.

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Article Synopsis
  • The study investigates the role of p63, a transcription factor, in skin aging and keratinocyte senescence, revealing that the depletion of p63 accelerates aging markers in both animal models and human cells.
  • Using advanced metabolomic analysis techniques, the research identifies key metabolic pathways linked to cell senescence that change when p63 is silenced, affecting stress markers and lipid production.
  • Findings suggest that p63 plays a crucial role in managing metabolic processes in keratinocytes, potentially offering insights into therapeutic strategies against skin aging and related conditions.
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