Publications by authors named "A F Richard"
The analytical quality of compounds subjected to high-throughput screening (HTS) impacts accurate interpretation of assay results, with poor quality samples potentially leading to false negatives or positives. The Tox21 "10K" library consists of over 8900 unique compounds, spanning a diverse landscape of environmental and pharmaceutical chemicals, posing opportunities and challenges for analytical quality control (QC) determinations. Tox21 sample plates stored in DMSO at ambient conditions for 0 (T0) and/or 4 months (T4), totaling more than 13K unique sample identifiers (Tox21 IDs), were subjected to various analyses, including liquid and gas chromatography mass spectrometry (LC-MS, GC-MS) and nuclear magnetic resonance (NMR).
View Article and Find Full Text PDFBCG remains the only licensed vaccine for tuberculosis (TB), but its efficacy wanes over time. Subunit vaccines, aim to improve BCG immunity and protection, by inducing responses to a few mycobacterial antigens delivered with a specific platform. Since the platform shapes the immune response induced, selecting the right platform has been challenging due to the lack of immune correlates of protection.
View Article and Find Full Text PDFMultiple myeloma (MM), a cancer of bone marrow plasma cells, is the second-most common hematological malignancy. However, despite immunotherapies like chimeric antigen receptor (CAR)-T cells, relapse is nearly universal. The bone marrow (BM) microenvironment influences how MM cells survive, proliferate, and resist treatment.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to understand how patients with myasthenia gravis (MG) perceive their condition and identify potential improvements in treatment.
- Patients over 12 months with the disease participated in an online survey, resulting in 246 completed responses.
- Key findings highlighted participants' desires for better physical activity, reduced fatigue, and suggested treatment improvements, including fewer side effects and simpler medication regimens.
Article Synopsis
- - The study aims to gather insights from neuropsychologists on their experiences with non-inclusive practices when assessing LGBTQ+ patients and share strategies for improving inclusivity in testing.
- - A survey was completed by 46 mainly doctoral-level neuropsychologists, revealing widespread encounters with non-inclusive language in assessment tools and a willingness to adapt practices accordingly.
- - Participants emphasized the need for more inclusive neuropsychological instruments and offered suggestions for enhancements, which will inform future research and advocacy efforts for better support of gender and sexual minorities.