[The effect of low doses of a synthetic analog of a quinoid radiotoxin on the viability of normal and gamma-irradiated animals].

The method for a production of synthetic quinoid radiotoxins in vitro has been developed and described. Synthetic quinoid radiotoxins like quinoid radiotoxins (qRT) which are being produced from irradiated tissues of the organisms have demonstrated high toxicity at relatively high qRT concentrations. However, when synthetic qRT is introduced into the organisms in ultra-small concentrations, one can observe the opposite action: the resistance of the organism increases and a number of essential functions are activated.

[Native protein activated by low doses of gamma radiation as a source of secondary biogenic radiation].

If is demonstrated that native protein of egg-white after being gamma-irradiated with law doses is able to stimulate transition of cells of remote biological detector from non-cycling state to proliferation even if irradiated protein is separated from detector by quartz-glass. Animal tissues which have a high protein content (freshly cut hair; insect bodies) reveal the same ability. The role of natural background radiation in the maintenance of energy excitation, state of living tissue proteins is discussed.

[The display of hormesis in the action of quinoid radiotoxins].

Two hours before irradiation (7.5 Gy) mice were injected with quinoid radiotoxins in concentrations close to those formed in mouse blood after gamma-irradiation with a dose of 10 cGy. This increased the survival rate (from 10-20% to 80%), prevented the radiation-induced weight loss, and increased catalase activity in the liver and blood of exposed animals.

[The importance of removing quinoid radiotoxins from the irradiated organism in the efficacy of hemosorption in the therapy of radiation sickness].

Sorption by SKN-2M coal of various endogenous substances, including quinones (tyrosine oxidation products) and quinoid radiotoxins (QR) isolated from gamma-irradiated plant and animal tissues has been studied. The fact that the precursors of QR-DOPA, tyrosine and QR, isolated from gamma-irradiated plant and animal tissues, are readily absorbed by the sorbent under study supports the major contribution of QR removal from the organism to the therapeutic effect of hemosorption after gamma irradiation of animals with minimal lethal doses.