Bioactive silicon-based dental gel associated with a calcium booster for dentin hypersensitivity treatment: A randomized clinical study.

Background: Dentin hypersensitivity affects a significant portion of the world's population, causing pain and negatively impacting oral health and quality of life This clinical study investigated the effectiveness of a desensitizing fluoride silicon-rich dental gel associated with a calcium booster.

Material And Methods: In this single-blind, randomized, parallel-group clinical trial, forty-eight volunteers diagnosed with dentin hypersensitivity and qualified to participate were randomized into 2 groups: (1) fluoride silicon-rich dental gel (REFX Technology)/calcium booster (Si/Ca protocol); (2) Pumice stone diluted in saline. A draw was carried out between the right and left sides of the patients so that either a prophylaxis with the dental gel associated with calcium or with fine pumice stone diluted in saline was carried out.

Situational Analysis of the Medication Practices in Brazilian Hospitals: A Multicenter Study.

Objective: To carry out a situational analysis of the medication practices in Brazilian hospitals through the Medication Safety Self-Assessment for Hospitals and the factors associated with better performance in the evaluation.

Methods: This is a multicenter cross-sectional study in which the results of the application of the Medication Safety Self-Assessment for Hospitals, between 2015 and 2020, in 30 Brazilian hospitals were described. In addition, whether the institutional profile was associated with higher self-assessment scores (better performance in the evaluation) was also evaluated.

Buthionine sulfoximine acts synergistically with doxorubicin as a sensitizer molecule on different tumor cell lines.

The chemotherapeutic drug doxorubicin (DOX) has been widely used for treating solid tumors attributed to its antiproliferative effectiveness; however, its clinical use is limited due to side effects, including cardiotoxicity, myelosuppression, and drug resistance. Combining DOX with buthionine sulfoximine (BSO), a glutathione (GSH) synthesis inhibitor, showed promising results in overcoming these adverse effects, potentially reducing the required DOX dose while maintaining efficacy. The aim of the present study was to examine the effects of different concentrations of BSO and DOX, both individually and in combination, utilizing B16/F10 (murine melanoma), SNB-19 (human glioblastoma), S180 (murine sarcoma), and SVEC4-10 (murine endothelial) cell lines.

Temporal Unfolding of Spelling-to-sound Mappings in Visual (Non)word Recognition.

Behavioral research has shown that inconsistency in spelling-to-sound mappings slows visual word recognition and word naming. However, the time course of this effect remains underexplored. To address this, we asked skilled adult readers to perform a 1-back repetition detection task that did not explicitly involve phonological coding, in which we manipulated lexicality (high-frequency words vs.

Different daily times for at-home bleaching with 10% carbamide peroxide: A randomized single-blind, noninferiority controlled trial.

Background: This single-blind, noninferiority trial evaluated whether 10% carbamide peroxide (CP) applied for 2 or 4 hours daily is noninferior to 8 hours.

Methods: A total of 120 healthy adults, with teeth shade A2 or darker, were randomly allocated to 3 groups (n = 40). All participants used 10% CP gel in a bleaching tray for 2, 4, and 8 hours daily for 14 days, with the option to extend treatment if they were dissatisfied.