[Coronectomy as a surgical treatment of impacted lower molars with mandibular canal close relationship].

Searching for third molars atraumatic removal method remains a challenge in oral surgery. Method of partial removal of impacted tooth leaving a non-extracted root in the wound becomes more popular recently. Determining medical indications for this method, as well as searching for standards for its implementation is important.

[Impacted third molar root abnormality with mandibular canal close position as a presupposing factor to inferior alveolar nerve trauma].

Objective: The aim of the study is reducing the risks of surgical injury to the inferior alveolar nerve, by taking into account individual topographic and anatomical features, improving diagnostic methods, and techniques for removing retinated teeth with a close fit to the mandibular canal.

Material And Methods: An examination was conducted in the Department of Surgical Dentistry (CBCT/OPG) and surgical treatment of 223 patients, with a close fit of the roots of the retinated lower third molar to the mandibular canal. Microslips of teeth with roots intact during removal (=96) of the main group and the control group (=52) were prepared with a Micromet Remet manual petrographic machine.

[Reduction in the need for glucocorticoids on the background of therapy with biologic disease-modifying antirheumatic drugs and Janus kinase inhibitors in rheumatoid arthritis: evidence from real clinical practice].

Background: Clinical guidelines for the treatment of rheumatoid arthritis (RA) recommend reducing the use of glucocorticoids (GCs) due to the high risk of associated complications.

Aim: To determine the frequency of GC cancellations and dose reductions in real clinical practice, while taking into account active RA therapy.

Materials And Methods: The study group consisted of 303 patients with RA reliable according to ACR/EULAR criteria (women 79.

Bioinspired Pyrano[2,3-]chromen-8-ones: Ring C-Opened Analogues of Calanolide A: Synthesis and Anti-HIV-1 Evaluation.

We have designed and synthesized a series of bioinspired pyrano[2,3-]coumarin-based Calanolide A analogs with anti-HIV activity. The design of these new calanolide analogs involved incorporating nitrogen heterocycles or aromatic groups in lieu of ring C, effectively mimicking and preserving their bioactive properties. Three directions for the synthesis were explored: reaction of 5-hydroxy-2,2-dimethyl-10-propyl-2,8-pyrano[2,3-]chromen-8-one with (i) 1,2,4-triazines, (ii) sulfonylation followed by Suzuki cross-coupling with (het)aryl boronic acids, and (iii) aminomethylation by Mannich reaction.

Outer membrane vesicles and the outer membrane protein OmpU govern biofilm matrix assembly.

Biofilms are matrix-encased microbial communities that increase the environmental fitness and infectivity of many human pathogens including . Biofilm matrix assembly is essential for biofilm formation and function. Known components of the biofilm matrix are the polysaccharide polysaccharide (VPS), matrix proteins RbmA, RbmC, Bap1, and extracellular DNA, but the majority of the protein composition is uncharacterized.