Publications by authors named "A F Petrov"
During biosimilar drug development, conducting a clinical trial of biosimilar efficacy in patients may become necessary in the presence of residual uncertainty regarding the biosimilarity of the drugs. In the development of the biosimilar romiplostim GP40141, we aimed to use a model-based in silico clinical trial (ISCT) approach to optimize the planned biosimilar efficacy trial in patients with immune thrombocytopenia. The population pharmacokinetic/pharmacodynamic model for healthy volunteers was modified and validated to describe platelet dynamics in patients with immune thrombocytopenia.
View Article and Find Full Text PDFObjective: To evaluate actual myocardial energy requirements using indirect calorimetry, oxygen delivery (DO), oxygen extraction ratio (OER), cardiac output (CO) and their components, as well as to study the impact of positive inotropic agent (dobutamine) on myocardial metabolism in early postoperative period after cardiac surgery.
Material And Methods: We measured the main metabolic parameters using indirect calorimetry in 20 patients after on-pump cardiac surgery with cardioplegia. To evaluate the impact of metabolic load on CO, VO and DO, we administered dobutamine 3 µg/kg/min at the second phase of the study.
Article Synopsis
- The study focuses on detecting multijet signatures from proton-proton collisions at a high energy of 13 TeV, analyzing a dataset totaling 128 fb^{-1}.
- A special data scouting method is utilized to pick out events with low combined momentum in jets.
- This research is pioneering in its investigation of electroweak particle production in R-parity violating supersymmetric models, particularly examining hadronically decaying mass-degenerate higgsinos, and it broadens the limits on the existence of R-parity violating top squarks and gluinos.
Switchable 3D Photonic Crystals Based on the Insulator-to-Metal Transition in VO.
ACS Appl Mater Interfaces
December 2024
Article Synopsis
- Photonic crystals (PhCs) are optical structures that manipulate light by creating a photonic band gap (PBG) through their dielectric properties, traditionally fixed and static.
- Recent advancements target switchable PhCs, especially using vanadium dioxide (VO), which changes its state and optical properties near room temperature, allowing for a reversible adjustment of the PBG.
- This research introduces a fabrication method for 3D switchable VO photonic crystals, demonstrating significant control over PBG at specific wavelengths in the near-infrared region, paving the way for versatile photonic devices that can adapt their functionalities.
The Impact of Climate, Aeroallergens, Pollution, and Altitude on Exercise-Induced Bronchoconstriction.
Immunol Allergy Clin North Am
February 2025
Article Synopsis
- Exercise-induced bronchoconstriction (EIB) can occur independently or alongside asthma, and its development is influenced by a variety of factors.
- Environmental elements such as climate, allergens, air pollution, and altitude can exacerbate EIB symptoms.
- Educating patients about how these environmental factors affect their condition may help them manage symptoms better and enhance their ability to exercise.