Grade-ADOLOPMENT of nephrology clinical practice guidelines and creation of referral algorithms for Pakistan.

Objective: To develop evidence-based local clinical practice guidelines and primary care referral pathways for general physicians to help streamline the management of glomerular diseases and diabetes in chronic kidney disease patients in Pakistan.

Methods: The study was conducted from October 2021 to February 2023 at the Centre for Clinical Best Practices, Aga Khan University Hospital, Karachi, in collaboration with the AKUH Section of Nephrology. Two source guidelines were selected by the local nephrologists after a thorough literature review on PubMed and Google Scholar.

Young Motorcyclists' Behavior Analysis in Pakistan based on Modified Motorcycle Rider Behavior Questionnaire (MRBQ).

In many low- and middle-income countries, including Pakistan, young motorcyclists are overrepresented in crashes, primarily due to risky behaviors. To examine these behaviors, the Motorcycle Rider Behavior Questionnaire (MRBQ) has been modified for young motorcyclists in Pakistan to better capture the unique and culturally relevant behaviors affecting their safety. In addition, the study seeks to identify the factor structure of the MRBQ tailored for young motorcyclists in Pakistan, explore the determinants of self-reported incidents (i.

Clinical Practice Guidelines for the Management of Type 2 Diabetes in South Asia: A Systematic Review.

Background: Clinical practice guidelines (CPGs) are a helpful tool for the evidence-based management of Type 2 Diabetes Mellitus (T2D). The aim of this systematic review was to synthesize and appraise the scope and quality of South Asian T2D CPGs.

Methods: This PROPSERO registered (CRD42023425150) systematic review adhered to the 2020 PRISMA guidelines.

Comparative effectiveness of antiplatelet therapies for saphenous venous graft occlusion and cardiovascular outcomes: a network meta-analysis.

Introduction: The ideal antiplatelet therapy to maintain graft patency after coronary artery bypass graft surgery (CABG) remains controversial. This review of randomized controlled trials (RCTs) aims to compare aspirin monotherapy, ticagrelor monotherapy, dual antiplatelet therapy (DAPT) with aspirin and ticagrelor (Asp+Tica) or with aspirin and clopidogrel (Asp+Clopi) to evaluate differences in post-CABG saphenous vein graft (SVG) occlusion, internal mammary artery (IMA) occlusion, myocardial infarction (MI), bleeding, and all-cause mortality (ACM) rates.

Evidence Acquisition: The literature review was conducted on several electronic databases, including Medline, Embase, and Cochrane Central, from inception to August 10, 2022.