Publications by authors named "A F Peerdeman"
Developmental exposure to carbamates, organophosphates, and pyrethroids has been associated with impaired neurodevelopmental outcomes. Sex-specific differences following chronic insecticide exposure are rather common in vivo. Therefore, we assessed the chronic effects of in vitro exposure to different carbamates (carbaryl, methomyl and aldicarb), organophosphates [chlorpyrifos (CPF), chlorpyrifos-oxon (CPO), and 3,5,6,trichloropyridinol (TCP)], and pyrethroids [permethrin, alpha-cypermethrin and 3-phenoxy benzoic acid (3-PBA)] on neuronal network development in sex-separated rat primary cortical cultures using micro-electrode array (MEA) recordings.
View Article and Find Full Text PDFArticle Synopsis
- Pesticides, including carbamates, organophosphates, organochlorines, and pyrethroids, are linked to health issues like neurotoxicity, with some studies indicating these effects can vary by sex.
- In experiments using female and male rat cortical cultures, specific pesticides were found to impact neuronal network function differently, suggesting carbaryl and organophosphates like CPF and CPO reduce neuronal activity, with CPO being the most impactful.
- The study highlights that certain pesticides can lead to increased or decreased neuronal activity, and that females may be more sensitive to specific compounds like endosulfan, demonstrating the importance of considering sex in neurotoxicity research.
Aim Of The Study: The coronavirus disease 2019 (COVID-19) pandemic significantly impacted cancer care. In this study, clinical patient characteristics related to COVID-19 outcomes and advanced care planning, in terms of non-oncological treatment restrictions (e.g.
View Article and Find Full Text PDFObjective: To find out which procedure was the safest for each indication for operation in diseases of the thyroid gland.
Design: Retrospective study.
Setting: Two teaching hospitals, The Netherlands.