An examination of factors contributing to different anesthesia models in underserved areas.

Background: Maternity care access is worsening across the United States, driven in part by difficulties staffing obstetric units in some hospitals. Certified registered nurse anesthetists (CRNAs) provide obstetric anesthesia services in underserved areas, including rural areas (Cohen et al., 2021; Martsolf et al.

Systematic characterization of zinc in a series of breast cancer cell lines reveals significant changes in zinc homeostasis.

An optimal amount of labile zinc (Zn ) is essential for proliferation of human cells, where Zn levels that are too high or too low cause cell cycle exit. Tumors of the breast have been characterized by high levels of total Zn . Given the role of Zn in proliferation of human cells and elevation of zinc in breast cancer tumors, we examined the concentration of total and labile Zn across a panel of 5 breast cancer cell lines, compared to the normal MCF10A cell line.

Project Synapse: Efficacy of a Youth Outreach Program to Increase Diversity in Neurosurgery.

Background: There is a lack of diversity within neurosurgery; in 2019, only 12%, 4%, and 5% of neurosurgeons identify as female, black, and Latinx respectively. Project Synapse, a youth outreach initiative, aims to diversify the neurosurgical workforce by exposing youth from underrepresented minority (URM) backgrounds to neurosurgery. The purpose of this manuscript is to describe the outcomes of the first 2 years of Project Synapse.

Asymptomatic female softball pitchers have altered hip morphology and cartilage composition.

Few studies have explored hip morphology and cartilage composition in female athletes or the impact of asymmetric repetitive loading, such as occurs during softball pitching. The current cross-sectional study assessed bilateral bony hip morphology on computed tomography imaging in collegiate-level softball pitchers ('Pitch1', n = 25) and cross-country runners ('Run', n = 13). Magnetic resonance imaging was used to assess cartilage relaxation times in a second cohort of pitchers ('Pitch2', n = 10) and non-athletic controls ('Con', n = 4).

TARGETING LUNG HEME IRON BY AEROSOL HEMOPEXIN ADMINSTRATION IN SICKLE CELL DISEASE PULMONARY HYPERTENSION.

Lung tissue from human patients and murine models of sickle cell disease pulmonary hypertension (SCD-PH) show perivascular regions with excessive iron accumulation. The iron accumulation arises from chronic hemolysis and extravasation of hemoglobin (Hb) into the lung adventitial spaces, where it is linked to nitric oxide depletion, oxidative stress, inflammation, and tissue hypoxia, which collectively drive SCD-PH. Here, we tested the hypothesis that intrapulmonary delivery of hemopexin (Hpx) to the deep lung is effective at scavenging heme-iron and attenuating the progression of SCD-PH.