Publications by authors named "A F Nikkels"
Shingles, also termed herpes zoster (HZ), is due to the reactivation of the varicella zoster virus (VZV) in a dorsal root nerve ganglion with an intra-axonal passage of the virus to a predetermined dermatome. The risk of HZ increases with age, as well as the morbidity risks. The most feared complication is post-herpetic neuralgia, defined as persisting pain sensations three months after the resolution of the skin lesions.
View Article and Find Full Text PDFBelgian recommendations for managing psoriasis in a changing treatment landscape.
J Eur Acad Dermatol Venereol
October 2024
Article Synopsis
- Targeted biologic drugs and small molecules have revolutionized psoriasis treatment, but their high cost presents a challenge for the Belgian healthcare system.
- Eight Belgian dermatologists conducted a quasi-Delphi initiative to evaluate current opportunities and challenges in psoriasis treatment, focusing on responsible and sustainable drug use.
- The update includes new treatment recommendations, insights on defining psoriasis severity, and the potential of teledermatology to enhance patient care while managing resources efficiently.
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis. Half of the cases are associated with an immune dysfunction and are frequently triggered by pathergy such as a tissular aggression via surgery or burn wounds. A patient with ulcerative colitis presented a PG at the site of an iontophoresis patch for tendinopathy.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the impact of high-dose vitamin D supplementation on melanoma relapse in patients who have had curatively resected cutaneous melanoma (CM).* -
- A total of 436 patients were randomly assigned to either a vitamin D treatment group, receiving 100,000 IU monthly, or a placebo group, with follow-up lasting up to 116 months.* -
- Results showed that while vitamin D supplementation significantly increased serum levels, it did not noticeably improve relapse-free survival or reduce melanoma-related deaths compared to the placebo group.*