Bioactive-based spray and spot-on formulations: development, characterization and in vitro efficacy against fleas and ticks.

The flea Ctenocephalides felis felis and the tick Rhipicephalus sanguineus are ectoparasites of great importance in veterinary medicine that can affect pets, also impacting the lives of owners due to the possible transmission of zoonoses. Due to the negative impact on animals, owners and the environment, synthetic chemicals are being replaced by natural alternatives. Eugenol and carvacrol stand out as bioactive substances with potential antiparasitic activity.

Well-managed grass is a key strategy for carbon storage and stabilization in anthropized Amazon soils.

Soils under anthropic use in the Amazon region are often associated with soil carbon (C) stock losses. More recently, the restoration of degraded pastures and the introduction of integrated systems have changed this pattern, and soil C accumulation is often observed. This study evaluated an 11-year field experiment to quantify soil C changes and elucidate C stabilization mechanisms in areas under anthropic uses in the southern Amazon of Brazil.

Purification of AAV8 through a scalable two-step monolithic chromatography approach.

Adeno-associated viruses (AAV) are becoming increasingly popular as a powerful tool for gene delivery therapy applications. Although processes to produce AAV are established, future demand for this type of viral vector requires further development of manufacturing processes to make them more robust, scalable, and flexible to accommodate the rise of engineered capsids. This study focuses on designing and evaluating a two-step chromatography process for capturing and polishing AAV8 using monolith chromatography media.

Average direct cost of peripherally inserted central catheterization by nurses in hospitalized patients: a cost estimate.

Objective: This study aimed to estimate the direct costs of peripherally inserted central catheterization by nurses for hospitalized patients.

Methods: A cost estimation study using a quantitative approach was conducted in a public teaching hospital in northern Paraná to calculate the direct costs of peripherally inserted central catheterization. The population included all medical records of patients between 15 and 99 years of age who were hospitalized and underwent peripherally inserted central catheterization by nurses between January 1, 2019, and December 31, 2021, totaling 664 insertions.

Teaching the history of nursing: an overview of Brazilian public universities.

Objective: To describe the teaching of the History of Nursing in the curricular structures of Undergraduate Nursing Courses at Brazilian public universities.

Method: A documentary, descriptive study with a qualitative approach carried out between February 2021 and August 2023. The sample included the curricula of active face-to-face undergraduate courses at public educational institutions (n=136) identified on the e-MEC platform.