Publications by authors named "A F Moon"
Background And Aims: Recently proposed "Rule-of-Five" criteria define compensated advanced chronic liver disease (cACLD) and clinically significant portal hypertension (CSPH) using liver stiffness (LS) and platelet count. We aimed to validate these criteria by determining whether they are associated with risk of adverse outcomes.
Approach And Results: Patients without prior hepatic decompensation or HCC who underwent LS and platelet measurements (n = 17,076) were categorized as follows: no cACLD (LS: 2.
Article Synopsis
- Patients with decompensated cirrhosis face higher COVID-19 risks, and the study analyzed outcomes based on demographics using SECURE-Liver and COVID-Hep databases.
- In North America, Black patients showed higher rates of hospitalization, ICU admission, and death compared to White patients, while Hispanic patients fared better. In Europe, White patients had more comorbidities but lower hospitalization rates than non-White patients.
- After adjusting for confounders, many disparities in COVID-19 outcomes became statistically insignificant, indicating that other health conditions might contribute to the increased risks rather than demographics alone.
Objective: To evaluate the prevalence of and characteristics associated with owner-reported gastrointestinal (GI) disease in companion dogs within the US.
Methods: Cross-sectional owner-reported survey study of 43,517 dogs enrolled in the DAP between December 26, 2019, and December 31, 2022. Dogs were grouped on the basis of having an owner-reported GI disorder (ORGID) versus not having that ORGID at any point in their history (control group).
Multiple Gastrointestinal Immune-Related Adverse Events From Immune Checkpoint Inhibitor Therapy.
Clin Transl Gastroenterol
November 2024
Introduction: We aimed to describe immune-related adverse events (irAEs) affecting multiple organs of the gastrointestinal system in patients who received immune checkpoint inhibitors.
Methods: Within a 2,843 patient retrospective cohort consisting of patients with cancer treated with immune checkpoint inhibitors, we used the Electronic Medical Record Search Engine, an information retrieval system, to search free text in the medical record to identify patients with multiple gastrointestinal irAEs.
Results: Thirteen patients developed multiple gastrointestinal irAEs (0.