Publications by authors named "A F Michael"
Background: The prevalence of chronic wounds is expected to rise with the increasing elderly population in the society. This rise in prevalence of chronic wounds comes with its consequences such as wound pain and interference with activities of daily living. There's a paucity of data on the impact of chronic wounds in our clime.
View Article and Find Full Text PDFPurpose: Hypospadias, one of the congenital anomalies commonly associated with some degrees of ventral penile curvature that may arise from malformation of dartos fascia, the chordee. Our study aims to determine the correlation between the histopathology properties of dartos fascia and the severity of ventral penile curvature in hypospadias.
Materials And Methods: One hundred hypospadias patients with various degrees of ventral penile curvature were included in this cross-sectional analytical study from 2020 to 2022.
Anemia and mineral and bone disorder (MBD) are significant complications of chronic kidney disease (CKD). The erythropoietin (Epo) pathway plays a key role in both of these processes in CKD. Another molecule that plays an important role in CKD-MBD is fibroblast growth factor (FGF)-23, whose main role is to maintain serum phosphate levels in the normal range, acting via its co-receptor Klotho; however, its activity may also be related to anemia and inflammation.
View Article and Find Full Text PDFArticle Synopsis
- A survey of 55 healthcare professionals in the UK explored current management practices for advanced epithelial ovarian cancer (OC), focusing on testing for homologous recombination deficiency (HRD) and BRCA mutations prior to maintenance treatment.
- All respondents emphasized the importance of considering cytoreductive surgery at first recurrence, with 65% advocating the use of DESKTOP III criteria to assist in decision-making.
- Healthcare professionals noted that most primary OC patients in the UK have established HRD and mutation status, underscoring the growing recognition of secondary cytoreduction's role in treatment.