Publications by authors named "A F Mele"
Article Synopsis
- - Hydrogels made from hyaluronic acid and agarose-carbomer are being studied for their potential to simultaneously deliver multiple drugs for different diseases, thanks to their biocompatibility and unique 3D structure.
- - The study focuses on how ethosuximide and sodium salicylate interact and diffuse within these hydrogels, using advanced techniques like NMR Spectroscopy to analyze their transport properties.
- - Findings suggest that when both drugs are loaded together, they behave similarly in their diffusion patterns, which may be influenced by drug-drug interactions, leading to a proposed trapping-release mechanism that affects how the drugs are released from the hydrogels.
Isatuximab, pomalidomide, and dexamethasone as salvage therapy for patients with multiple myeloma: the Italian, multicenter, retrospective clinical experience with 270 cases outside of controlled clinical trials.
Haematologica
November 2024
Article Synopsis
Since March 2019, a non-communicable diseases program has been established at hospital level, with enrollment and clinical reassessment every 6 months. Since July 2023, monthly enrollment and visits have also been conducted at health center level. This study aimed at assessing the adherence to scheduled follow-up visits following the decentralization of the integrated NCDs program from Hospital to Health Center level and investigate factors influencing follow-up adherence.
View Article and Find Full Text PDFMicroRNAs are well established as master regulators of carcinogenesis and potential biomarkers in breast cancer (BC). In a preliminary effort, we found miR-27a-5p to be significantly downregulated in experimentally derived mammospheres and BC patients from The Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) dataset. Herein, we sought to investigate the putative involvement of miR-27a-5p in promoting a migratory phenotype of breast cancer cells, and establish whether miR-27a-5p is associated with patient clinicopathological characteristics.
View Article and Find Full Text PDFLymphoma and plasma cell disorders are the most common indications for autologous hematopoietic stem cell (HSC) transplantation. We conducted a prospective multicenter study with the aim of testing the feasibility of plerixafor (PLX) in combination with R-DHAP and G-CSF in 37 patients with relapsed refractory diffuse large B-cell lymphoma (R/R DLBCL) in order to collect a large number of HSC with a goal of transplantation. After R-DHAP, daily monitoring of peripheral blood CD34 + cells by flow cytometry was performed starting on day + 13.
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