Publications by authors named "A F Markham"
In vertebrates, glucocorticoids can be upregulated in response to both psychosocial and energetic stressors, making it difficult to identify the cause of elevated glucocorticoid concentrations when both types of stressors are present. This problem has been particularly challenging in studies of social dominance rank in wild animals. In contrast to glucocorticoids, thyroid hormone concentrations are largely unaffected by psychosocial stressors and therefore offer a better estimate of energetic challenges.
View Article and Find Full Text PDFPurpose: Rapid genetic testing in the critical care setting may guide diagnostic evaluation, direct therapies, and help families and care providers make informed decisions about goals of care. We tested whether a simplified DNA extraction and library preparation process would enable us to perform ultra-rapid assessment of genetic risk for a Mendelian condition, based on information from an affected sibling, using long-read genome sequencing and targeted analysis.
Methods: Following extraction of DNA from cord blood and rapid library preparation, genome sequencing was performed on an Oxford Nanopore PromethION.
Article Synopsis
- * Advances in computing and machine learning offer solutions for automatic analysis of acoustic data, but the field is still developing and faces challenges in bridging the gap between biology and technology.
- * This review outlines trends in bioacoustic PAM, introduces machine learning applications, and offers a practical guide for researchers on building automatic detection systems while highlighting future directions in the field.
Article Synopsis
- Social group composition influences fitness in female baboons, especially during critical periods like early lactation when competition for resources peaks among mothers with infants.
- The study revealed that as more females in a group had young infants, female-female aggression increased, leading to higher infant mortality rates.
- Findings suggest that both aggressive interactions among mothers and potential infanticide by younger females can discourage synchronous birthing, impacting reproductive behaviors in this species.
A biallelic (AAGGG) expansion in the poly(A) tail of an AluSx3 transposable element within the gene RFC1 is a frequent cause of cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS), and more recently, has been reported as a rare cause of Parkinson's disease (PD) in the Finnish population. Here, we investigate the prevalence of RFC1 (AAGGG) expansions in PD patients of non-Finnish European ancestry in 1609 individuals from the Parkinson's Progression Markers Initiative study. We identified four PD patients carrying the biallelic RFC1 (AAGGG) expansion and did not identify any carriers in controls.
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