Rational design, synthesis, biological evaluation, molecular docking, and molecular dynamics of substituted uracil derivatives as potent anti-cancer agents.

An efficient synthesis of a series of uracil analogous was performed to obtain new potential anticancer agents. The cytotoxic effect of the synthesized derivatives was assessed in vitro against three cancer cell lines, namely hepatic cancer (HepG-2), colon cancer (HCT-116), and breast cancer (MCF-7). Among the tested compounds, 5, 11 and 15 stood as potent uracil derivatives with pan cytotoxicity against the 3 cell lines out-performing the reference compound 5-FU.

Comprehensive characterization of high-risk coding and non-coding single nucleotide polymorphisms of human CXCR4 gene.

CXCR4, a chemokine receptor known as Fusin or CD184, spans the outer membrane of various human cells, including leukocytes. This receptor is essential for HIV infection as well as for many vital cellular processes and is implicated to be associated with multiple pathologies, including cancers. This study employs various computational tools to investigate the molecular effects of disease-vulnerable germ-line missense and non-coding SNPs of the CXCR4 gene.

Prevalence and risk factors of long covid and its associated adverse work outcomes among workers in the manufacturing sector in Malaysia - a mixed-methods study protocol.

Background: The manufacturing sector in Malaysia has been severely impacted by the COVID-19 pandemic. This is further exacerbated by Long COVID-19 symptoms among the manufacturing workers, which are proven to influence work performance and quality of life. Of note, there is currently a lack of knowledge regarding the burden of Long COVID-19 in the Malaysian manufacturing sector.

Discovery of Staircase Chirality through the Design of Unnatural Amino Acid Derivatives.

Chirality has garnered significant attention in the scientific community since its discovery by Louis Pasteur over a century ago. It has been showing a profound impact on chemical, biomedical, and materials sciences. Significant progress has been made in controlling molecular chirality, as evidenced by the several Nobel Prizes in chemistry awarded in this area, particularly for advancements in the asymmetric catalytic synthesis of molecules with central and axial chirality.

Numerical evaluation of bi-facial ZnO/MoTe photovoltaic solar cells with N-doped CuO as the BSF layer for enhancing device simulation.

Molybdenum telluride (MoTe) shows great promise as a solar absorber material for photovoltaic (PV) cells owing to its wide absorption range, adjustable bandgap, and lack of dangling bonds at the surface. In this research, a basic device structure comprising Pt/MoTe/ZnO/ITO/Al was developed, and its potential was assessed using the SCAPS-1D software. The preliminary device exhibited a photovoltaic efficiency of 23.