Publications by authors named "A F Hickman"
Members of the piggyBac superfamily of DNA transposons are widely distributed in host genomes ranging from insects to mammals. The human genome has retained five piggyBac-derived genes as domesticated elements although they are no longer mobile. Here, we have investigated the transposition properties of piggyBat from Myotis lucifugus, the only known active mammalian DNA transposon, and show that its low activity in human cells is due to subterminal inhibitory DNA sequences.
View Article and Find Full Text PDFIn an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
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- Pseudomonas aeruginosa causes respiratory infections in cystic fibrosis patients and produces a virulence factor called Cif, which worsens patient outcomes by decreasing CFTR levels and disrupting healing signals.!* -
- The virulence factor Cif is regulated by a protein called CifR, which is the first known bacterial transcriptional regulator that senses epoxides, although how it functions at a molecular level has not been fully explored.!* -
- Through biochemical and structural studies, researchers revealed how CifR binds to DNA and identified key changes in its structure that facilitate gene regulation, highlighting the critical role of the Cys107 residue in sensing epoxides and releasing DNA.!*
Objectives: To determine baseline prevalence of proteinuria and albuminuria among participants from the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) and evaluate associated risk factors.
Design: Cross sectional analysis of a baseline sample of participants from the REPRIEVE Trial.
Methods: REPRIEVE is an international primary cardiovascular prevention randomized controlled trial (RCT) of pitavastatin calcium vs.