SURFBAT: a surrogate family-based association test building on large imputation reference panels.

Genotype-phenotype association tests are typically adjusted for population stratification using principal components that are estimated genome-wide. This lacks resolution when analysing populations with fine structure and/or individuals with fine levels of admixture. This can affect power and precision, and is a particularly relevant consideration when control individuals are recruited using geographic selection criteria.

How local reference panels improve imputation in French populations.

Imputation servers offer the exclusive possibility to harness the largest public reference panels which have been shown to deliver very high precision in the imputation of European genomes. Many studies have nonetheless stressed the importance of 'study specific panels' (SSPs) as an alternative and have shown the benefits of combining public reference panels with SSPs. But such combined approaches are not attainable when using external imputation servers.

Opening the Black Box of Imputation Software to Study the Impact of Reference Panel Composition on Performance.

Genotype imputation is widely used to enrich genetic datasets. The operation relies on panels of known reference haplotypes, typically with whole-genome sequencing data. How to choose a reference panel has been widely studied and it is essential to have a panel that is well matched to the individuals who require missing genotype imputation.

Growing for good: producing a healthy, low greenhouse gas and water quality footprint diet in Aotearoa, New Zealand.

Food production plays a central role in the health of humanity and our environment. New Zealand produces a large amount of food, but it is unknown if it can produce enough of the right crops in the places to better the health of New Zealanders, profitably, while maintaining New Zealand's primary production exports and meeting ambitions to lower greenhouse gas (GHGs) emissions and nutrient losses to water. We tested two scenarios that aimed at delivering a healthy diet while maximising profit and minimising GHGs (climate-focused scenario) or losses of nitrogen (N) and phosphorus (P) to water (freshwater-focused scenario).