Publications by authors named "A F Gotardo"
The effect of breed on ivermectin residues in the edible tissues of cattle and the estimated withdrawal period.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
November 2024
This study analyzed the residue depletion kinetics of ivermectin (IVM) in Nelore and crossbred (Nelore x Angus) cattle aiming to compare the profiles between the breeds and evaluate the residue levels at the injection site. IVM 1%, at a dose of 0.2 mg/kg, was administered the subcutaneous route, and tissue samples were collected on different days post administration for analysis by LC-MS/MS.
View Article and Find Full Text PDFDetection and Analysis of Florfenicol Residues and Metabolites in Nile Tilapia (Oreochromis niloticus) Tissues Post-Oral Administration in Tropical Waters.
J Vet Pharmacol Ther
September 2024
Article Synopsis
- - Water temperature significantly affects fish metabolism, and this study focused on how tilapia metabolize the antibiotic florfenicol (FF) at temperatures typical for tropical and subtropical regions.
- - Tilapia were given a daily dose of 10 mg/kg of FF for 10 days, with tissue samples taken during and after treatment to analyze concentrations of FF and its metabolites using a validated laboratory method.
- - The findings showed that FF concentration was highest in the kidney, while the primary metabolite, florfenicol alcohol (FFOH), was most prevalent in the liver and fillet, highlighting the efficient absorption and elimination of FF in tilapia raised in warm water.
Antimicrobial growth promoters (AGPs) in animal production have been related to the increase in multidrug-resistant bacteria. The AGP ban in many countries has highlighted the growing need for alternatives for feed additives. Considering the non-antibiotic anti-inflammatory theory of AGPs, chicks received three different doses of sodium salicylate (SS) in feed (10, 30, 90 mg/kg), basal diet (BD) was used as a negative control, and zinc bacitracin (ZB) was used as a positive control.
View Article and Find Full Text PDFArticle Synopsis
- Leucaena leucocephala is a plant used for food that contains a toxic compound called L-mimosine, which has potential cancer treatment properties due to its ability to chelate metal ions.
- This study aimed to understand how L-mimosine affects immune responses in Wistar rats by administering varying doses (25, 40, and 60 mg/kg) over 28 days.
- Results showed no signs of toxicity, but a decrease in T-dependent immune responses at the highest dose and enhanced phagocytosis by macrophages at medium to high doses, indicating that while L-mimosine inhibited certain immune functions, it did not compromise macrophage activity.
Article Synopsis
- * This study examined the toxicity of L-mimosine in adult Wistar rats, administering varying doses over 28 days, and assessed various health parameters including weight gain, feed intake, hormonal levels, and organ health.
- * Findings revealed no significant clinical toxicity, but histopathological analysis indicated thyroid lesions and hormonal disruptions, including lowered testosterone levels, which suggest that L-mimosine may impair male reproductive function.