Publications by authors named "A F Gembre"
The Effect of Lacticaseibacillus rhamnosus, Lacticaseibacillus paracasei, and Bifidobacterium animalis ssp. lactis on the Prevention of Asthma in an Animal Model.
Probiotics Antimicrob Proteins
October 2024
Article Synopsis
- The rise in asthma cases, especially in urban areas, has led to research on preventive measures, driven by the hygiene theory which suggests early exposure to infections may protect against allergic diseases.
- The study evaluated the effects of three specific probiotics (Lacticaseibacillus rhamnosus, Lacticaseibacillus paracasei, and Bifidobacterium animalis ssp. lactis) on asthma using mice, testing different concentrations over 26 days prior to allergen exposure.
- Results showed that none of the probiotics effectively reduced asthma-related symptoms like airway inflammation and bronchial hyperresponsiveness, indicating that the effectiveness of probiotics varies by strain and dosage, prompting the need for further research.
There is evidence that IL-22 and IL-17 participate in the pathogenesis of allergic asthma. To investigate the role of IL-22, we used IL-22 deficient mice (IL-22 KO) sensitized and challenged with ovalbumin (OVA) and compared with wild type (WT) animals exposed to OVA. IL-22 KO animals exposed to OVA showed a decreased number and frequency of eosinophils, IL-5 and IL-13 in the airways, reduced mucus production and pulmonary inflammation.
View Article and Find Full Text PDFA low-grade and persistent inflammation, which is the hallmark of obesity, requires the participation of NLRP3 and cell death. During Mycobacterium tuberculosis infection, NLRP3 signaling is important for bacterial killing by macrophages in vitro but was shown to be dispensable for host protection in vivo. We hypothesized that during obesity-tuberculosis (TB) comorbidity, NLRP3 signaling might play a detrimental role by inducing excessive inflammation.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between gut microbiota and lung health, particularly how obesity-induced gut dysbiosis may worsen tuberculosis infection and lung inflammation.
- Using a mouse model of high-fat diet-induced obesity and subsequent TB infection, the researchers found increased susceptibility and inflammation in obese mice.
- The findings emphasize the potential of modifying gut microbiota as a therapeutic strategy for improving responses to tuberculosis, especially in individuals with obesity-related complications.
Tuberculosis kills more than 1 million people every year, and its control depends on the effective mechanisms of innate immunity, with or without induction of adaptive immune response. We investigated the interaction of type II alveolar epithelial cells (AEC-II) infected by Mycobacterium tuberculosis with dendritic cells (DCs). We hypothesized that the microenvironment generated by this interaction is critical for the early innate response against mycobacteria.
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