Publications by authors named "A F G Quest"
Article Synopsis
- Oral squamous cell carcinoma (OSCC) is the most common oral cancer, often developing from dysplasia, a pre-cancerous condition.
- The Wnt/β-catenin signaling pathway contributes to OSCC by promoting the growth and survival of cancer cells, with Porcupine (PORCN) being a crucial enzyme in this process.
- Research shows higher PORCN levels in severe dysplasia and poorly differentiated OSCC, and using LGK974, a PORCN inhibitor, decreased oral lesion size in mice, indicating its potential as a therapeutic target in OSCC treatment.
Article Synopsis
- Inflammation is the body's natural response to injury or infection, but if it becomes chronic, it can lead to serious health issues like obesity, cancer, and heart disease.
- Chronic low-grade inflammation is increasingly common and is linked to rising global health problems, highlighting a pressing need for intervention.
- The review explores current understanding and knowledge gaps about chronic inflammation's role in various diseases and suggests future research directions to combat its effects.
Metastasis is the leading cause of cancer-related deaths, making the development of novel, more effective therapies imperative to alleviate patient suffering. Metabolic switching is a hallmark of cancer cells that facilitates metastasis. Cancer cells obtain most of their energy and intermediate metabolites, which are required to proliferate and metastasize, through aerobic glycolysis.
View Article and Find Full Text PDFPeriodontitis, characterized by persistent inflammation in the periodontium, is intricately connected to systemic diseases, including oral cancer. Bacteria, such as and , play a pivotal role in periodontitis development because they contribute to dysbiosis and tissue destruction. Thus, comprehending the interplay between these bacteria and their impacts on inflammation holds significant relevance in clinical understanding and treatment advancement.
View Article and Find Full Text PDFAlkylidene cyclopropanes (ACPs) are valuable synthetic intermediates because of their constrained structure and opportunities for further diversification. Although routes to ACPs are known, preparations of ACPs with control of both the configuration of the cyclopropyl ( vs ) group and the geometry of the alkene ( vs ) are unknown. We describe enzymatic cyclopropanation of allenes with ethyl diazoacetate (EDA) catalyzed by an iridium-containing cytochrome (Ir(Me)-CYP119) that controls both stereochemical elements.
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