How does autophagy impact neurological function?

Autophagies describe a set of processes in which cells degrade their cytoplasmic contents via various routes that terminate with the lysosome. In macroautophagy (the focus of this review, henceforth autophagy), cytoplasmic contents, including misfolded proteins, protein complexes, dysfunctional organelles, and various pathogens, are captured within double membranes called autophagosomes, which ultimately fuse with lysosomes, after which their contents are degraded. Autophagy is important in maintaining neuronal and glial function; consequently, disrupted autophagy is associated with various neurologic diseases.

Navigating the maze of active ageing measurement: untangling methodological and theoretical issues in the UJACAS questionnaire.

Active Ageing (AA) involves maintaining engagement in physical, social, and mental activities in older adulthood, reflecting societal values and political agendas. Despite various measurement tools, there is no universal standard. The University of Jyväskylä Active Ageing Scale (UJACAS) is increasingly used in Europe but faces inconsistencies from varying response scales across versions.

Ultrasonic Evaluation of the Corpus Luteum in Alpacas With Embryo Removal on Day 9 Post-Mating.

The objective of the present study was to determine the diameter, area, circumference, and blood flow of the corpus luteum (CL) using transrectal ultrasonography in female alpacas with and without the presence of an embryo on Day 9 post-mating, the time of maternal recognition of pregnancy (MRP). For this purpose, 12 female alpacas with follicles ≥ 7 mm were mated with fertile males and treated with 0.0084 mg of buserelin acetate (Day 0).

A Prospective, Non-interventional Observational Study to Assess the Efficacy, Safety, and Tolerability of the Casein Hydrolysate-Based Food Supplement in High-Risk Human Papillomavirus-Positive Women.

Objective The study aimed to assess the efficacy, safety, and tolerability of casein hydrolysate-based food supplement, HuPaVir, in high-risk human papillomavirus (HR-HPV)-positive women. Methods A prospective, multicenter, and non-interventional observational study was carried out in Spain. At the end of the study, 118 HR-HPV-positive women (20 to 65 years old) were enrolled and completed the follow-up as required by the protocol.

Ablative CO Laser Treatment of Rhinophyma in People of Color: A Case Series.

Rhinophyma is the result of progressive acne rosacea, which results in hypertrophy and fibrosis of sebaceous glands and connective tissues of the nose. The skin soft tissue envelope of the nose becomes bulkier and heavier relative to the underlying structural supportive framework of the nose over time, resulting in nasal airway obstruction and disfigurement that adversely impact quality of life. It is classically taught that rhinophyma is a disease that more commonly affects men, White people, and those in middle age.