Publications by authors named "A F E Rump"
Nefecon, a targeted-release capsule formulation of budesonide approved for the reduction of proteinuria in adults with primary immunoglobulin A nephropathy, targets overproduction of galactose-deficient immunoglobulin A type 1 in the Peyer's patches at the gut mucosal level. To investigate whether the commercial formulation of Nefecon capsules reliably releases budesonide to the distal ileum, a human study was conducted with test capsules reproducing the delayed-release function of Nefecon capsules. Caffeine was included in the test capsules as a marker for capsule opening in the gut since it appears rapidly in saliva after release from orally administered dosage forms.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how fluids move through the small intestine, focusing on drug absorption and dissolution under different conditions (fasting vs. after a meal).
- It uses MRI technology to track ingested water marked with manganese gluconate, examining transit times and distribution in 9 human subjects.
- Results indicate that water moves rapidly through the small intestine in both fasting and fed states, with some instances showing quicker transit in the postprandial state, providing insights into how food impacts drug absorption.
Multiple sclerosis (MS) is an inflammatory autoimmune disorder of the central nervous system and the leading cause of progressive neurological disability in young adults. It decreases the patient's lifespan by about 10 years and affects women more than men. No medication entirely restricts or reverses neurological degradation.
View Article and Find Full Text PDFArticle Synopsis
- Gastric emptying is crucial for understanding how drugs work in the body, leading to the development of various measurement methods, including a salivary tracer technique using an ice capsule with caffeine.
- The ice capsule, while effective, has issues like melting too soon and being hard to prepare, especially for older individuals, prompting the creation of a new compression-coated tablet.
- A clinical trial showed that both the ice capsule and the new tablet produced similar caffeine levels in saliva, indicating that the tablet is a viable alternative for measuring gastric emptying, including in special populations.
Ready-to-fill enteric hard capsule shells are an evolving field of oral drug and nutraceutical products. Lonza Capsugel Enprotect capsules were recently proven to provide reliable release in the small intestine after fasted intake, but robustness against postprandial intake needed to be proven. In this study, the capsules were administered to 16 healthy young subjects after intake of a light meal.
View Article and Find Full Text PDF