Publications by authors named "A F Donado"
Article Synopsis
- Thoracic aortic aneurysm (TAA) is often sporadic and more common in patients with a bicuspid aortic valve (BAV), although the reasons for this are not fully understood.
- The study examined differences in molecular characteristics between aortic dilatation in patients with BAV and those with a tricuspid aortic valve (TAV) by analyzing vascular smooth muscle cells and plasma proteins.
- Findings revealed that BAV-TAA patients experience higher oxidative stress and DNA damage, while distinct plasma markers suggest a need for tailored treatment strategies for BAV and TAV patients.
Background: Pseudoaneurysms of the sinus of Valsalva are infrequent cardiac pathologies that usually involve a single sinus.
Material And Methods: We present a case of a 63-year-old male who was diagnosed with ascending aortic aneurysm during a routine echocardiogram.
Conclusion: We report here a patient with giant pseudoaneurysms of two sinuses of Valsalva who successfully underwent a sinus of Valsalva reconstruction.
Purpose: Successful pregnancy following cardiac transplantation has been described, although outcome data from individual centers are relatively sparse. We investigated maternal and fetal outcomes including change in left ventricular (LV) function and calcineurin inhibitor (CNI) dose in women who became pregnant from our institution.
Methods: We identified every female patient <49 years at the time of transplant who survived >3 months post-surgery, between 1985 and 2014.
Background: HLA class I molecules are divided into classic (Ia) and nonclassic (Ib). Nonclassic HLA molecules (E, F, and G) have acquired relevance owing to their immunomodulatory properties and possible repercussions for induction of tolerance in organ transplantation. The objective of this study was to identify the impact of these molecules on transplant success or failure.
View Article and Find Full Text PDFCoronary atherosclerosis still represents the major cause of mortality in western societies. Initiation of atherosclerosis occurs within the intima, where major histological and molecular changes are produced during pathogenesis. So far, proteomic analysis of the atherome plaque has been mainly tackled by the analysis of the entire tissue, which may be a challenging approach because of the great complexity of this sample in terms of layers and cell type composition.
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