Publications by authors named "A F Contino"
Extracellular vesicles (EVs) are well-known membrane-limited particles secreted by both healthy and cancerous cells. They are considered as biomarkers for early cancer diagnosis and are involved in many pathologies and physiological pathways. They could serve as diagnostic tools in liquid biopsies, as therapeutics in regenerative medicine, or as drug delivery vehicles.
View Article and Find Full Text PDFLanthanide-doped nanoparticles, featuring sharp emission peaks with narrow bandwidth, exhibit high downconversion luminescence intensity, making them highly valuable in the fields of bioimaging and drug delivery. High-crystallinity YO nanoparticles (NPs) doped with Er ions were functionalized by using a pegylation procedure to confer water solubility and biocompatibility. The NPs were thoroughly characterized using transmission electron microscopy (TEM), inductively coupled plasma mass spectrometry (ICP-MS), and photoluminescence measurements.
View Article and Find Full Text PDFArticle Synopsis
- The GRAd-COV2 vaccine, developed from a gorilla adenovirus, aims to enhance COVID-19 immunity with a focus on a stable spike protein.
- In a phase 2 trial with 917 participants, the vaccine demonstrated good safety and strong immune responses, especially after a second dose.
- The vaccine effectively generated a robust T cell response, particularly CD8 T cells, suggesting its potential for future genetic vaccine development in combating variants of concern.