Lanternfish as bioindicator of microplastics in the deep sea: A spatiotemporal analysis using museum specimens.

We investigated MP ingestion in lanternfishes (Myctophidae), one of the most abundant vertebrates in the world, using archived specimens from museum collections from 1999 to 2017. Microplastics were detected in 55 % of the 1167 specimens analysed (0.95 ± 1.

Outcomes of an Emergency Department opioid alternatives Program implemented within a safety-net hospital system.

Background: The ongoing opioid epidemic in the United States has reinforced the need to provide multimodal and non-opioid pain management interventions. The PAMI-ED ALT program employed a multifaceted approach in the Emergency Department (ED) developing electronic health record (EHR) pain management order panels and discharge panels, as well as educating patients, clinicians, and ED staff on opioid alternatives, including non-pharmacologic interventions. The primary objective of this analysis was to compare changes in opioid and non-opioid analgesic administrations and prescribing in ED patients with select pain conditions (renal colic, headache, low back, and non-low back musculoskeletal pain) before and after implementation of PAMI ED-ALT.

LAP1 Interactome Profiling Provides New Insights into LAP1's Physiological Functions.

The nuclear envelope (NE), a protective membrane bordering the nucleus, is composed of highly specialized proteins that are indispensable for normal cellular activity. Lamina-associated polypeptide 1 (LAP1) is a NE protein whose functions are just beginning to be unveiled. The fact that mutations causing LAP1 deficiency are extremely rare and pathogenic is indicative of its paramount importance to preserving human health, anticipating that LAP1 might have a multifaceted role in the cell.

Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality.

Background: Lipids play a critical role in defense against sepsis. We sought to investigate gene expression and lipidomic patterns of lipid dysregulation in sepsis.

Methods: Data from four adult sepsis studies were analyzed and findings were investigated in two external datasets.

[Patients' perceptions of teleconsultation in long-term follow-up after pediatric cancer].

For the past decade, "long-term follow-up consultations" have been established for adults cured of pediatric cancer to ensure the prevention, early detection, and treatment of long-term effects. These consultations are now sometimes conducted in the form of teleconsultations, a practice that has seen significant growth following the COVID-19 crisis. The objective of this study was to evaluate the satisfaction, usefulness, and patient experience of teleconsultations conducted by an oncologist or hematologist as part of the long-term follow-up of adults cured of pediatric cancer.